Rahul Khade (rkhade)

Rahul Khade

Lecturer

Charles V. Schaefer, Jr. School of Engineering and Science

Chemistry and Chemical Biology, Chemistry and Chemical Biology

Edwin A. Stevens Hall 410

Education

  • PhD (2016) Stevens Institute of Technology (Chemical Biology)
  • MS (2013) Stevens Institute of Technology (Chemical Biology)
  • MS (2010) USM (Public Health (Epidemiology and Biostatistics))

Research

My research interest is in quantum chemical studies of biocatalytic processes in chemistry, chemical biology, biochemistry and biology. Focusing on heme enzymes biocatalyst catalyzed chemical, biological, and pharmaceutical processes with green synthesis. Detailed understanding of reactions mechanisms in chemical reactions of interest, and effect of protein environmental in biological systems to fine tune biocatalyst to increase its efficiency and reducing toxic waste to the environment and promoting sustainable chemical options.

Institutional Service

  • Undergraduate Education Committee Member

Honors and Awards

Outstanding Achievement Award in PhD Degree in Chemical Biology
Scholarship Award: Dr. Ajay Bose Memorial Endowed & Term Scholarship Fund

Professional Societies

  • ACS – American Chemical Society Member
  • IMC – Indian Medical Council Member

Selected Publications

Journal Article

1. Rahul Khade, Erwin Abucayon, Douglas Powell, George Richter-Addo, Yong Zhang
Insights Into the Observed Trans-Bond Length Variations Upon NO Binding to Ferric and Ferrous Porphyrins with Neutral Axial Ligands
Journal: ACS Omega, 2021, 6, 24777-24787

2. Shiliang Tian, Ruixi Fan, Therese Albert, Rahul L. Khade, Huiguang Dai, Kevin A. Harnden, Parisa Hosseinzadeh, Jing Liu, Mark J. Nilges, Yong Zhang, Pierre Moenne-Loccoz, Yisong Guo, Yi Lu
Stepwise Nitrosylation of the Nonheme Iron Site in an Engineered Azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins.
Journal: Chemical Science 2021, 12, 6569-6579

3. Erwin G. Abucayon, Jia-Min Chu, Megan Ayala, Rahul L. Khade, Yong Zhang, George B. Richter- Addo.
Insight Into the Preferential N-Binding versus O-Binding of Nirtosoarenes to Ferrous and Ferric Heme Centers
Journal: Dalton Transactions, 2021, 50, 3487-3498

4. Erwin G. Abucayon, Rahul L. Khade, Douglas R. Powell, Yong Zhang, George B. Richter-Addo
Not Limited to Iron: A Cobalt Heme-NO Model Facilitates N-N Coupling with External NO in the Presence of a Lewis Acid to Generate N2O
Journal: Angewandte Chemie International Edition, 2019, 58, 51, 18598-18603.

5. David A. Vargas, Rahul L. Khade, Yong Zhang, Rudi Fasan
Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3- Dihydrobenzofuran-Based Tricyclic Scaffolds
Journal: Angewandte Chemie International Edition, 2019, 58, 30, 10148-10152.

6. Rahul L. Khade, Ajay L. Chandgude, Rudi Fasan, Yong Zhang
Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions
Journal: ChemCatChem, 2019, 11, 13, 3101-3108.

7. Joseph J. Gair, Yehao Qiu, Rahul L. Khade, Natalie H. Chan, Alexander S. Filatov, Yong Zhang, Jared C. Lewis
Synthesis, Characterization, and Theoretical Investigation of a Transition State Analogue for Proton Transfer during C-H Activation by a Rhodium-Pincer Complex
Journal: Organometallics, 2019, 38, 7, 1407-1412.

8. Satish R. Malwal, Bing O’Dowd, Xinxin Feng, Petri Turhanen, Christopher Shin, Jiaqi Yao, Boo Kyung Kim, Noman Baig, Tianhui Zhou, Sandhya Bansal, Rahul L. Khade, Yong Zhang, Eric Oldfield
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
Journal: Journal of American Chemical Society, 2018, 140, 24, 7568-7578.

9. Satish R. Malwal, Jian Gao, Xiangying Hu, Yunyun Yang, Weidong Liu, Jian-Wen Huang, Tzu-Ping Ko, Liping Li, Chun-Chi Chen, Bing O’Dowd, Rahul L. Khade, Yong Zhang, Yonghui Zhang, Eric Oldfield, Rey-Ting Guo.
Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes
Journal: ACS Catalysis, 2018, 8, 5, 4299-4312.

10. Erwin G. Abucayon, Rahul L. Khade, Douglas R. Powell, Yong Zhang, George B. Richter-Addo
Lewis Acid Activation of the Ferrous Heme-NO Fragment toward the N-N Coupling Reaction with NO To Generate N2O
Journal: Journal of American Chemical Society, 2018, 140, 12, 4204-4207.

11. Rahul L. Khade and Yong Zhang
C-H Insertions by Iron Porphyrin carbene: Basic Mechanism and Origin of Substrate Selectivity
Journal: Chemistry A European Journal, 2017, 23, 70, 17654-17658.

12. Rahul L. Khade, Yuwei Yang, Yelu Shi, Yong Zhang
HNO-Binding in Heme Proteins: Effects of Iron Oxidation State, Axial Ligand, and Protein Environment
Journal: Angewandte Chemie International Edition, 2016, 55, 48, 150583-15061.

13. Erwin G. Abucayon, Rahul L. Khade, Douglas R. Powell, Michael J. Shaw, Yong Zhang, George B. Richter-Addo
Over or Under: Hydride Attack at the Metal versus the Coordinated Nitrosyl Ligand in Ferric Nitrosyl Porphyrins
Journal: Dalton Transactions, 2016, 45, 18259-18266.

14. Erwin G. Abucayon, Rahul L. Khade, Douglas R. Powell, Yong Zhang, George B. Richter-Addo
Hydride Attack on a Coordinated Ferric Nitrosyl: Experimental and DFT Evidence for the Formation of a Heme Model-HNO Derivative
Journal: Journal of the American Chemical Society, 2016, 138, 1, 104-107.

15. Rahul L. Khade and Yong Zhang
Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand
Journal: Journal of the American Chemical Society, 2015, 137, 24, 7560-7563.

16. Xianqi Kong, Victor V. Terskikh, Rahul L. Khade, Liu Yang, Amber Rorick, Yong Zhang, Peng He, Yining Huang, Gang Wu
Solid-State 17O NMR Spectroscopy of Paramagnetic Coordination Compounds
Journal: Angewandte Chemie International Edition, 2015, 54, 16, 4753-4757.

17. Freneil B. Jariwala, John A. Hibbs, Carl S. Weisbecker, John Ressler, Rahul L. Khade, Yong Zhang, Athula B. Attygalle
A Distonic Radical-Ion for Detection of Traces of Adventitious Molecular Oxygen (O2) in Collision Gases Used in Tandem Mass Spectrometers
Journal: Journal of The American Society for Mass Spectrometry, 2014, 25, 9, 1670-1673.

18. Rahul L. Khade, Wenchao Fan, Yan Ling, Liu Yang, Eric Oldfield, Yong Zhang
Iron Porphyrin Carbenes as Catalytic Intermediates: Structures, Mössbauer and NMR Spectroscopic Properties, and Bonding**
Journal: Angewandte Chemie International Edition, 2014, 53, 29, 7574-7578.

19. Jikun Li, Ke Wang, Tatyana I. Smirnova, Rahul L. Khade, Yong Zhang, Eric Oldfield
Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis?**
Journal: Angewandte Chemie International Edition, 2013, 52, 25, 6522-6525.

20. Yang Ling, Rahul L. Khade, Yong Zhang
Structural, EPR Superhyperfine, and NMR Hyperfine Properties of the Cu-Octarepeat Binding Site in the Prion Protein
Journal: The Journal of Physical Chemistry B, 2011, 115, 11, 2663-2670.

21. Amit Kumar, LaMaryet Moody, Jason F. Olaivar, Nerissa A. Lewis, Rahul L. Khade, Alvin A. Holder, Yong Zhang, Vijayaraghavan Rangachari
Inhibition of Ab42 Peptide Aggregation by a Binuclear Ruthenium (II)- Platinum (II) Complex: Potential for Multimetal Organometallics as Anti-amyloid Agents
Journal: ACS Chemical Neuroscience, 2010, 1, 10, 691-701.

Courses

CH-115 General Chemistry I
CH-116 General Chemistry II
CH-321 Thermodynamics
CH-421 Chemical Dynamics and Lab
CH-520 Advanced Physical Chemistry
CH-620 Thermodynamics and Kinetics