Ilke Uguz (iuguz)

Ilke Uguz

Assistant Professor

Charles V. Schaefer, Jr. School of Engineering and Science

Department of Biomedical Engineering

Education

  • Ph.D. (2017) École des Mines de Saint-Étienne (Microelectronics)
  • M.S. (2013) Dresden Technical University (Biophysics)
  • B.S. (2010) Yildiz Technical University (Electrical Engineering)

Research

Design and microfabrication of organic, soft and flexible neural implants.
Large-scale electrophysiology and neural stimulation.
In vivo ion pumps and microfluidics for chemical stimulation.
Neural imaging and optogenetics.

General Information

One of the most exciting topics of our decade is developing interfaces with the brain’s vast network to enable precise communication between neurons and computers, aiming to tackle neurodegenerative diseases and better understand brain dynamics. Dr. Uguz's research mainly focuses on design and development of ultra-flexible and light weight neural implants that can generate a more tissue compatible interface. By miniaturizing the recording sites, Dr. Uguz aims to develop very large-scale systems capable of recording or stimulating brain activity with single neuronal resolution over extended periods without causing tissue damage.

Experience

Assistant Professor, Biomedical Engineering, Stevens Institute of Technology

Postdoctoral Researcher, Electrical Engineering, Columbia University

PhD, Electrical Engineering, École des Mines de Saint-Étienne

Master of Science, Biophysics, Technical University of Dresden

Bachelor's degree, Electrical Engineering, Yildiz Technical University

Institutional Service

  • IACUC Member
  • MS/PhD Recruitment Committee Member
  • PhD admission Committee Member
  • Qualification exam committee Member
  • Admitted Student Weekend 2025 Member
  • BMES Member

Professional Service

  • IEEE EDS on biomedical devices Technical committee member
  • SPIE Advisory board member

Appointments

Assistant Professor
Charles V. Schaefer, Jr. School of Engineering and Science
Department of Biomedical Engineering

Professional Societies

  • BMES – Biomedical Engieering Society Member
  • MRS – Material Research Society Member

Selected Publications

Conference Proceeding

  1. Gilhotra, Y.; Yilmaz, S.; Pollmann, E.; Choi, J.; Overhauser, H.; Yin, H.; Dubey, A.; Wingel, K.; Uguz, I.; Pesaran, B.; Shepard, K.; Roe, A. W.; Shoham, S. (2025). CMOS bioelectronics for optical neural interfaces. Optogenetics and Optical Manipulation 2025 (pp. 11). SPIE.
    https://doi.org/10.1117/12.3049550.
  2. Arslan, V.; Jadwiszczak, J.; Sherman, J.; Uguz, I.; Shepard, K. L. (2024). Monolithic Fabrication of Micron-Scale Piezo-Polymer Transducers on CMOS. 2024 IEEE International Electron Devices Meeting (IEDM) (pp. 1-4). IEEE.
    https://doi.org/10.1109/iedm50854.2024.10873315.
  3. Arslan, V.; Karatum, O.; Sherman, J.; Jadwiszczak, J.; Muthuraman, P.; Yilmaz, S.; Uguz, I.; Li, L.; Shepard, K. L. (2024). A 206-Element, 250-µW/channel, 87-MHz Ultrasound Linear-Array Receiver with Monolithically Integrated Transducers for Photoacoustic Tomography. 2024 IEEE European Solid-State Electronics Research Conference (ESSERC) (pp. 428-431). IEEE.
    https://doi.org/10.1109/esserc62670.2024.10719404.

Journal Article

  1. Abrahamsson, T.; Ek, F.; Cornuéjols, R.; Byun, D.; Savvakis, M.; Bruschi, C.; Sahalianov, I.; Miglbauer, E.; Musumeci, C.; Donahue, M. J.; Petsagkourakis, I.; Gryszel, M.; Hjort, M.; Gerasimov, J. Y.; Baryshnikov, G.; Kroon, R.; Simon, D. T.; Berggren, M.; Uguz, I.; Olsson, R.; Strakosas, X. (2026). Visible‐Light‐Driven Aqueous Polymerization Enables in Situ Formation of Biocompatible, High‐Performance Organic Mixed Conductors for Bioelectronics. Angewandte Chemie (2 ed., vol. 138). Wiley.
    https://doi.org/10.1002/ange.202517897.
  2. Jung, T.; Zeng, N.; Fabbri, J. D.; Eichler, G.; Li, Z.; Zabeh, E.; Das, A.; Willeke, K.; Wingel, K. E.; Dubey, A.; Huq, R.; Sharma, M.; Hu, Y.; Ramakrishnan, G.; Tien, K.; Mantovani, P.; Parihar, A.; Yin, H.; Oswalt, D.; Misdorp, A.; Uguz, I.; Shinn, T.; Rodriguez, G. J.; Nealley, C.; Sanborn, S.; Gonzales, I.; Roukes, M.; Knecht, J.; Yoshor, D.; Canoll, P.; Spinazzi, E.; Carloni, L. P.; Pesaran, B.; Patel, S.; Jacobs, J.; Youngerman, B.; Cotton, R. J.; Tolias, A.; Shepard, K. L. (2025). Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device. openRxiv.
    https://doi.org/10.1101/2024.05.17.594333.
  3. Pollmann, E. H.; Yin, H.; Uguz, I.; Dubey, A.; Wingel, K. E.; Choi, J. S.; Moazeni, S.; Gilhotra, Y.; Andino-Pavlovsky, V.; Banees, A.; Parihar, A.; Boominathan, V.; Robinson, J. T.; Veeraraghavan, A.; Pieribone, V. A.; Pesaran, B.; Shepard, K. L. (2024). A subdural CMOS optical device for bidirectional neural interfacing. Nature Electronics (9 ed., vol. 7, pp. 829-841). Springer Science and Business Media LLC.
    https://doi.org/10.1038/s41928-024-01209-w.
  4. Saleh, A.; Koklu, A.; Uguz, I.; Pappa, A.; Inal, S. (2024). Bioelectronic interfaces of organic electrochemical transistors. Nature Reviews Bioengineering (7 ed., vol. 2, pp. 559-574). Springer Science and Business Media LLC.
    https://doi.org/10.1038/s44222-024-00180-7.
  5. Uguz, I.; Ohayon, D.; Yilmaz, S.; Griggs, S.; Sheelamanthula, R.; Fabbri, J. D.; McCulloch, I.; Inal, S.; Shepard, K. L. (2024). Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants. Science Advances (12 ed., vol. 10). American Association for the Advancement of Science (AAAS).
    https://doi.org/10.1126/sciadv.adi9710.
  6. Uguz, I.; Ohayon, D.; Arslan, V.; Sheelamanthula, R.; Griggs, S.; Hama, A.; Stanton, J. W.; McCulloch, I.; Inal, S.; Shepard, K. L. (2024). Flexible switch matrix addressable electrode arrays with organic electrochemical transistor and pn diode technology. Nature Communications (1 ed., vol. 15). Springer Science and Business Media LLC.
    https://doi.org/10.1038/s41467-023-44024-1.
  7. Taal, A. J.; Uguz, I.; Hillebrandt, S.; Moon, C.; Andino-Pavlovsky, V.; Choi, J.; Keum, C.; Deisseroth, K.; Gather, M. C.; Shepard, K. L. (2023). Optogenetic stimulation probes with single-neuron resolution based on organic LEDs monolithically integrated on CMOS. Nature Electronics (9 ed., vol. 6, pp. 669-679). Springer Science and Business Media LLC.
    https://doi.org/10.1038/s41928-023-01013-y.
  8. Uguz, I.; Shepard, K. L. (2022). Spatially controlled, bipolar, cortical stimulation with high-capacitance, mechanically flexible subdural surface microelectrode arrays. Science Advances (42 ed., vol. 8). American Association for the Advancement of Science (AAAS).
    https://doi.org/10.1126/sciadv.abq6354.
  9. Shor, E.; Herrero-Vidal, P.; Dewan, A.; Uguz, I.; Curto, V. F.; Malliaras, G. G.; Savin, C.; Bozza, T.; Rinberg, D. (2022). Sensitive and robust chemical detection using an olfactory brain-computer interface. Biosensors and Bioelectronics (vol. 195, pp. 113664). Elsevier BV.
    https://doi.org/10.1016/j.bios.2021.113664.
  10. Ohayon, D.; Savva, A.; Du, W.; Paulsen, B. D.; Uguz, I.; Ashraf, R. S.; Rivnay, J.; McCulloch, I.; Inal, S. (2021). Influence of Side Chains on the n-Type Organic Electrochemical Transistor Performance. ACS Applied Materials & Interfaces (3 ed., vol. 13, pp. 4253-4266). American Chemical Society (ACS).
    https://doi.org/10.1021/acsami.0c18599.
  11. Proctor, C. M.; Uguz, I.; Slezia, A.; Curto, V.; Inal, S.; Williamson, A.; Malliaras, G. G. (2019). An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo. Advanced Biosystems (2 ed., vol. 3). Wiley.
    https://doi.org/10.1002/adbi.201800270.
  12. Pappa, A. M.; Ohayon, D.; Giovannitti, A.; Maria, I. P.; Savva, A.; Uguz, I.; Rivnay, J.; McCulloch, I.; Owens, R. M.; Inal, S. (2018). Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor. Science Advances (6 ed., vol. 4). American Association for the Advancement of Science (AAAS).
    https://doi.org/10.1126/sciadv.aat0911.
  13. Ganji, M.; Kaestner, E.; Hermiz, J.; Rogers, N.; Tanaka, A.; Cleary, D.; Lee, S. H.; Snider, J.; Halgren, M.; Cosgrove, G. R.; Carter, B. S.; Barba, D.; Uguz, I.; Malliaras, G. G.; Cash, S. S.; Gilja, V.; Halgren, E.; Dayeh, S. A. (2018). Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring. Advanced Functional Materials (12 ed., vol. 28). Wiley.
    https://doi.org/10.1002/adfm.201700232.
  14. Uguz, I.; Proctor, C. M.; Curto, V. F.; Pappa, A.; Donahue, M. J.; Ferro, M.; Owens, R. M.; Khodagholy, D.; Inal, S.; Malliaras, G. G. (2017). A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials (27 ed., vol. 29). Wiley.
    https://doi.org/10.1002/adma.201701217.
  15. Mantione, D.; del Agua, I.; Schaafsma, W.; ElMahmoudy, M.; Uguz, I.; Sanchez-Sanchez, A.; Sardon, H.; Castro, B.; Malliaras, G. G.; Mecerreyes, D. (2017). Low-Temperature Cross-Linking of PEDOT:PSS Films Using Divinylsulfone. ACS Applied Materials & Interfaces (21 ed., vol. 9, pp. 18254-18262). American Chemical Society (ACS).
    https://doi.org/10.1021/acsami.7b02296.
  16. ElMahmoudy, M.; Inal, S.; Charrier, A.; Uguz, I.; Malliaras, G. G.; Sanaur, S. (2017). Tailoring the Electrochemical and Mechanical Properties of PEDOT:PSS Films for Bioelectronics. Macromolecular Materials and Engineering (5 ed., vol. 302). Wiley.
    https://doi.org/10.1002/mame.201600497.
  17. Uguz, I.; Ganji, M.; Hama, A.; Tanaka, A.; Inal, S.; Youssef, A.; Owens, R. M.; Quilichini, P. P.; Ghestem, A.; Bernard, C.; Dayeh, S. A.; Malliaras, G. G. (2016). Autoclave Sterilization of PEDOT:PSS Electrophysiology Devices. Advanced Healthcare Materials (24 ed., vol. 5, pp. 3094-3098). Wiley.
    https://doi.org/10.1002/adhm.201600870.
  18. Jonsson, A.; Inal, S.; Uguz, I.; Williamson, A. J.; Kergoat, L.; Rivnay, J.; Khodagholy, D.; Berggren, M.; Bernard, C.; Malliaras, G. G.; Simon, D. T. (2016). Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site. Proceedings of the National Academy of Sciences (34 ed., vol. 113, pp. 9440-9445). Proceedings of the National Academy of Sciences.
    https://doi.org/10.1073/pnas.1604231113.
  19. Inal, S.; Rivnay, J.; Hofmann, A. I.; Uguz, I.; Mumtaz, M.; Katsigiannopoulos, D.; Brochon, C.; Cloutet, E.; Hadziioannou, G.; Malliaras, G. G. (2016). Organic electrochemical transistors based on PEDOT with different anionic polyelectrolyte dopants. Journal of Polymer Science Part B: Polymer Physics (2 ed., vol. 54, pp. 147-151). Wiley.
    https://doi.org/10.1002/polb.23938.
  20. Williamson, A.; Rivnay, J.; Kergoat, L.; Jonsson, A.; Inal, S.; Uguz, I.; Ferro, M.; Ivanov, A.; Sjöström, T. A.; Simon, D. T.; Berggren, M.; Malliaras, G. G.; Bernard, C. (2015). Controlling Epileptiform Activity with Organic Electronic Ion Pumps. Advanced Materials (20 ed., vol. 27, pp. 3138-3144). Wiley.
    https://doi.org/10.1002/adma.201500482.

posted-content

  1. Jung, T.; Zeng, N.; Fabbri, J. D.; Eichler, G.; Li, Z.; Zabeh, E.; Das, A.; Willeke, K.; Wingel, K. E.; Dubey, A.; Huq, R.; Sharma, M.; Hu, Y.; Ramakrishnan, G.; Tien, K.; Mantovani, P.; Parihar, A.; Yin, H.; Oswalt, D.; Misdorp, A.; Uguz, I.; Shinn, T.; Rodriguez, G. J.; Nealley, C.; Sanborn, S.; Gonzales, I.; Roukes, M.; Knecht, J.; Yoshor, D.; Canoll, P.; Spinazzi, E.; Carloni, L. P.; Pesaran, B.; Patel, S.; Jacobs, J.; Youngerman, B.; Cotton, R. J.; Tolias, A.; Shepard, K. L. (2025). Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device. openRxiv.
    https://doi.org/10.1101/2024.05.17.594333.

Courses

Digital Signal Processing
Biosensors and Bioinstrumentation