Xiaojun Yu (xyu)

Xiaojun Yu

Professor and Associate Chair of Graduate Studies in the Department of Biomedical Engineering

McLean Hall 301
(201) 216-8196

Education

  • PhD (2002) Case Western Reserve University (Biomedical Engineering)
  • MS (1992) Peking Union Medical College (Biomedical Engineering)
  • BE (1989) Tsinghua University (Polymer Materials and Chemical Engineering)

Research

Dr. Yu's primary research interests focus on tissue engineering, polymeric biomaterials and drug delivery. His current research activities include nano- and micro-scale functionalization of biomimic three-dimensional scaffolds for neural and musculoskeletal tissue repair and regeneration, investigation of cell and material interactions in bioreactors, development of controlled release systems for the delivery of growth factors and drugs, manipulation of microenvironment for stem cell proliferation and differentiation.
Visit the Yu Laboratory

Experience

Professor (09/20-present), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
Associate Professor (09/11-08/20), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
Assistant Professor (06/05-08/11), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
Research Associate (04/03-06/05), Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA
Research PostDoc Associate (11/01-03/03), Department of Chemical Engineering, Drexel University, Philadelphia, PA

Institutional Service

  • Associate Chair for BME Graduate Program Chair
  • Graduate Curriculum Committee (GCC) Member
  • Biosafety Committee Member
  • Department Graduate Curriculum Committee (GCC); Chair
  • Department P&T Committee Member
  • Departmental PhD Qualify Exam Committee Member
  • PhD in Data Science Oversight Committee Member
  • Schafer School of Engineering and Science Graduate Study Committee Member
  • Biomedical Engineering PhD admission committee Member
  • Schafer School of Engineering and Science P&T committee Member
  • Ad hoc reviewer for Schafer School of Engineering and Science research proposal enhancement program Member
  • Department Chair Search Committee Member
  • Biomedical Engineering Graduate Committee Member
  • Biomedical Engineering Master’s program committee Chair
  • Institute Curriculum Committee (ICC) Member
  • Biomedical Engineering Program Committee Member
  • Biomedical Engineering Faculty Search Committee Chair
  • Schafer School of Engineering and Science Faculty Advisory Council Member
  • CHI tissue engineering workshop group Member

Professional Service

  • Reviewing proposals - Panel member; Reviewed proposals submitted to NIH MTE panel; reviewing proposals.

Patents and Inventions

Xiaojun Yu, Paul Lee. BIPHASIC OSTEOCHONDRAL SCAFFOLD FOR RECONSTRUCTION OF ARTICULAR CARTILAGE. US patent no. 9180223; Issued: November 10, 2015.


Xiaojun Yu, Wei Chang. IMPLANTABLE NERVE CONDUIT HAVING A POLYMER FIBER SPIRAL GUIDANCE CHANNEL. US patent no. 9585666; issued: March, 6, 2017.

Selected Publications

Book

  1. Yu, X.; Laurencin, C. (2019). Regenerative Engineering. Encyclopedia of Biomedical Engineering. Elsevier Publication.

Book Chapter

  1. Mir, S.; Anwar, A.; Dulijan, I.; Kumar, A.; Yu, X. (2020). Protein and peptide nanofiber matrices for the regenerative medicine. Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization and Applications (pp. 327-350). Cambridge, MA: Woodhead Publishing.
  2. Jassal, M.; Junka, R.; Laurencin, C.; Yu, X. (2019). Introduction to Regenerative Engineering. Regenerative Engineering for the Encyclopedia of Biomedical Engineering (pp. 624-630). Elsevier Publication.

Conference Proceeding

  1. Kumar, A.; Yu, X. (2019). Biodegradable PCL-PLGA-beta TCP scaffolds for bone tissue engineering. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium (vol. 40, pp. 147).
  2. Kumar, A.; Yu, X. (2019). Development of spiral scaffolds with 3D printing-based combinatorial technologies for bone tissue engineering. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium (vol. 40, pp. 970).

Journal Article

  1. Anwar, A.; Petrino, Jr, D. J.; Alstine, N. V.; Yu, X. (2022). Biodegradable Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering.. Methods in molecular biology (Clifton, N.J.) (vol. 2394, pp. 693-711).
  2. Sonker, M.; Bajpai, S.; Khan, M. A.; Yu, X.; Tiwary, S. K.; Shreyash, N. (2021). Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer.. ACS applied bio materials (12 ed., vol. 4, pp. 8080-8109).
  3. Yu, X. (2021). Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment. Bioactive Materials (9 ed., vol. 6, pp. 2881-2893).
  4. Kumar, A.; Mir, S. M.; Aldulijan, I.; Mahajan, A.; Anwar, A.; Leon, C. H.; Terracciano, A.; Zhao, X.; Su, T. L.; Kalyon, D. M.; Kumbar, S. G.; Yu, X. (2021). Load-bearing biodegradable PCL-PGA-beta TCP scaffolds for bone tissue regeneration. Journal of Biomedical Materials Research - Part B Applied Biomaterials (2 ed., vol. 109, pp. 193-200).
  5. Zhou, X.; Zhou, G.; Junka, R.; Chang, N.; Anwar, A.; Wang, H.; Yu, X. (2021). Fabrication of polylactic acid (PLA)-based porous scaffold through the combination of traditional bio-fabrication and 3D printing technology for bone regeneration.. Colloids and surfaces. B, Biointerfaces (vol. 197, pp. 111420).
  6. Kumar, A.; Mir, S. M.; Aldulijan, I.; Mahajan, A.; Anwar, A.; Leon, C. H.; Terracciano, A.; Zhao, X.; Su, T.; Kalyon, D. M.; Kumbar, S. G.; Yu, X. (2020). Load-bearing biodegradable PCL-PGA-beta TCP scaffolds for bone tissue regeneration.. Journal of biomedical materials research. Part B, Applied biomaterials.
  7. Junka, R.; Yu, X. (2020). Polymeric nanofibrous scaffolds laden with cell-derived extracellular matrix for bone regeneration. Materials Science and Engineering C (vol. 113).
  8. Zhou, G.; Chang, W.; Zhou, X.; Chen, Y.; Dai, F.; Anwar, A.; Yu, X. (2020). Nanofibrous Nerve Conduits with Nerve Growth Factors and Bone Marrow Stromal Cells Pre-Cultured in Bioreactors for Peripheral Nerve Regeneration.. ACS applied materials & interfaces (14 ed., vol. 12, pp. 16168-16177).
  9. Chang, W.; Shah, M. B.; Zhou, G.; Walsh, K.; Rudraiah, S.; Kumbar, S. G.; Yu, X. (2020). Polymeric nanofibrous nerve conduits coupled with laminin for peripheral nerve regeneration.. Biomedical materials (Bristol, England) (3 ed., vol. 15, pp. 035003).
  10. Junka, R.; Quevada, K.; Yu, X. (2020). Acellular polycaprolactone scaffolds laden with fibroblast/endothelial cell-derived extracellular matrix for bone regeneration. Journal of Biomedical Materials Research - Part A (2 ed., vol. 108, pp. 351-364).
  11. Kumar, A.; Zhang, Y.; Terracciano, A.; Zhao, X.; Su, T.; Kalyon, D. M.; Katebifar, S.; Kumbar, S. G.; Yu, X. (2019). Load-bearing biodegradable polycaprolactone-poly (lactic-co-glycolic acid)-beta tri-calcium phosphate scaffolds for bone tissue regeneration. Polymers for Advanced Technologies (5 ed., vol. 30, pp. 1189--1197). Wiley Online Library.
  12. Shah, M. B.; Chang, W.; Zhou, G.; Glavy, J. S.; Cattabiani, T.; Yu, X. (2019). Novel spiral structured nerve guidance conduits with multichannels and inner longitudinally aligned nanofibers for peripheral nerve regeneration. Journal of Biomedical Materials Research - Part B Applied Biomaterials (5 ed., vol. 107, pp. 1410-1419).
  13. Manoukian, O. S.; Stratton, S.; Arul, M. R.; Moskow, J.; Sardashti, N.; Yu, X.; Rudraiah, S.; Kumbar, S. G. (2019). Polymeric ionically conductive composite matrices and electrical stimulation strategies for nerve regeneration: In vitro characterization. Journal of Biomedical Materials Research - Part B Applied Biomaterials (6 ed., vol. 107, pp. 1792-1805).
  14. Kumar, A.; Zhang, Y.; Terracciano, A.; Zhao, X.; Su, T. L.; Kalyon, D. M.; Katebifar, S.; Kumbar, S. G.; Yu, X. (2019). Load-bearing biodegradable polycaprolactone-poly (lactic-co-glycolic acid)- beta tri-calcium phosphate scaffolds for bone tissue regeneration. Polymers for Advanced Technologies (5 ed., vol. 30, pp. 1189-1197).
  15. Savitsky, K.; Yu, X. (2019). Combined strategies for tumor immunotherapy with nanoparticles. Clinical and Translational Oncology.
  16. Chung, R.; Kalyon, D. M.; Yu, X.; Valdevit, A. (2018). Segmental bone replacement via patient-specific, three-dimensional printed bioresorbable graft substitutes and their use as templates for the culture of mesenchymal stem cells under mechanical stimulation at various frequencies. Biotechnology and Bioengineering (9 ed., vol. 115, pp. 2365-2376).
  17. Junka, R.; Valmikinathan, C. M.; Kalyon, D. M.; Yu, X. (2013). Laminin functionalized biomimetic nanofibers for nerve tissue engineering. Journal of Biomaterials and Tissue Engineering (4 ed., vol. 3, pp. 494-502).
  18. Ergun, A.; Yu, X.; Valdevit, A.; Ritter, A.; Kalyon, D. M. (2012). Radially and axially graded multizonal bone graft substitutes targeting critical-sized bone defects from polycaprolactone/hydroxyapatite/tricalcium phosphate. Tissue Engineering - Part A (23-24 ed., vol. 18, pp. 2426-2436).
  19. Ergun, A.; Yu, X.; Valdevit, A.; Ritter, A.; Kalyon, D. M. (2011). In vitro analysis and mechanical properties of twin screw extruded single-layered and coextruded multilayered poly(caprolactone) scaffolds seeded with human fetal osteoblasts for bone tissue engineering. Journal of Biomedical Materials Research - Part A (3 ed., vol. 99 A, pp. 354-366).
  20. Ozkan, S.; Kalyon, D. M.; Yu, X. (2010). Functionally graded β-TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering. Journal of Biomedical Materials Research - Part A (3 ed., vol. 92, pp. 1007-1018).
  21. Ozkan, S.; Kalyon, D. M.; Yu, X.; McKelvey, C. A.; Lowinger, M. (2009). Multifunctional protein-encapsulated polycaprolactone scaffolds: Fabrication and in vitro assessment for tissue engineering. Biomaterials (26 ed., vol. 30, pp. 4336-4347).
  22. Degirmenbasi, N.; Ozkan, S.; Kalyon, D. M.; Yu, X. (2009). Surface patterning of poly(L-lactide) upon melt processing: In vitro culturing of fibroblasts and osteoblasts on surfaces ranging from highly crystalline with spherulitic protrusions to amorphous with nanoscale indentations. Journal of Biomedical Materials Research - Part A (1 ed., vol. 88, pp. 94-104).

Other

  1. Xi, Y.; Choi, C.; Yu, X.; Liang, J. (2020). Artificial Cornea with Double-Side Microtextured pHEMA Hydrogel.
  2. Tolias, P.; Ritter, A.; Yu, X.; Wang, H.; Du, H.; Choi, C.; Zhang, W.; Gu, Y.; Lee, W. (2013). Microfluidic-based cell-culturing platform and method.

Review, Journal

  1. Savitsky, K.; Yu, X. (2019). Combined strategies for tumor immunotherapy with nanoparticles. Clinical and Translational Oncology.