Jennifer Kang-Mieler
George Meade Bond Endowed Professor and Chair, Department of Biomedical Engineering
Charles V. Schaefer, Jr. School of Engineering and Science
Department of Biomedical Engineering
Research
Ocular drug delivery systems, Retinal imaging, Biomarkers, Retinal hemodynamics and electrophysiology
General Information
Dr. Kang-Mieler’s translational NIH-supported research projects include ocular drug delivery, retinal imaging and biomarkers, retinal blood flow, and electrophysiology. Her clinical interests include retinal vascular diseases such as age-related macular degeneration and diabetic retinopathy.
Experience
Education:
Northwestern University, Evanston IL
B.A. in Mathematics
M.S. in Applied Mathematics
Ph.D. in Biomedical Engineering
University of Illinois at Chicago, Chicago, IL
Post-doctoral research, Department of Ophthalmology and Visual Sciences
Northwestern University, Evanston IL
B.A. in Mathematics
M.S. in Applied Mathematics
Ph.D. in Biomedical Engineering
University of Illinois at Chicago, Chicago, IL
Post-doctoral research, Department of Ophthalmology and Visual Sciences
Institutional Service
- Master's Curriculum Committee Member
- Center for Health Innovation (CHI) Chair
- Faculty Search Committee Chair
- PhD Curriculum Committee Member
- UG Curriculum Committee Member
- SES Strategic Planning Committee Chair
Professional Service
- Midwest Ocular Angiography Conference (MOAC) Conference Director and Coordinator
- NIH Brain Imaging, Vision, Bioengineering and Low Vision Technology Development (BIVT)
- Northeast Biomedical Engineering League Executive Committee Secretary
- VentureWell and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) DEBUT Undergraduate Biomedical Design and Innovation Competition Judge
- Northeast Bioengineering Conference Conference Chair
- BMES Council of Chairs Education Summit Conference co-chair
- CoC BME Council of Chairs
- NIH NEI R61/R33 Translational Research Program Panel Chair and grant reviewer
- Propelify Innovation Festival BetterWellness Challenge Judge
Honors and Awards
Walter P. Murphy Fellowship, Graduate Fellowship, Northwestern University
General Electric Faculty of the Future Intern Fellowship, General Electric and McCormick School of Engineering and Applied Science, Northwestern University
Nelson Fellowship Award, Nelson Foundation and the Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago
Whitaker Foundation Fellow
Fellow of Association for Research in Vision and Ophthalmology (FARVO-Silver)
Pan-American Association of Ophthalmology (PAAO) and Retina Research Foundation (RRF) Paul Kayser Global Award
Asia-Pacific Academy of Ophthalmology (APAO) Achievement Award
Fellow of Association for Research in Vision and Ophthalmology (FARVO-Gold)
Club Jules Gonin and Retina Research Foundation Award
General Electric Faculty of the Future Intern Fellowship, General Electric and McCormick School of Engineering and Applied Science, Northwestern University
Nelson Fellowship Award, Nelson Foundation and the Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago
Whitaker Foundation Fellow
Fellow of Association for Research in Vision and Ophthalmology (FARVO-Silver)
Pan-American Association of Ophthalmology (PAAO) and Retina Research Foundation (RRF) Paul Kayser Global Award
Asia-Pacific Academy of Ophthalmology (APAO) Achievement Award
Fellow of Association for Research in Vision and Ophthalmology (FARVO-Gold)
Club Jules Gonin and Retina Research Foundation Award
Professional Societies
- AIMBE – American Institute for Medical and Biological Engineering (AIMBE) Fellow
- Club Jules Gonin Member
- International Retinal Imaging Society Member
- PAAO – Pan-American Association of Ophthalmology (PAAO) Member
- Dowling Society Member
- SWE – Society for Women Engineers (SWE) Member
- Macula Society Member
- Retina Society Member
- Association for Ocular Pharmacology and Therapeutics Member
- International Society on Oxygen Transport to Tissue Member
- ASEE – American Society for Engineering Education (ASEE) Member
- ISCEV – International Society for Clinical Electrophysiology of Vision (ISCEV) Member
- ARVO – Association for Research in Vision and Ophthalmology (ARVO) Fellow
- BMES – Biomedical Engineering Society (BMES) Member
- ASRS – American Society of Retina Specialists (ASRS) Member
Grants, Contracts and Funds
Principal Investigator: National Institute of Health (R01) (R01 EY029298). “Sustained Ocular Drug Delivery System for Anti-VEGF Agents”
Principal Investigator: National Institute of Health (R01) (R01 EY032222) “Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy (DR)”
Principal Investigator: National Institute of Health (R01) (R01 EY036203) “Deep Learning-based Diagnosis of Retinopathy of Prematurity"
Co-Investigator: Center for Equine Health Research Grant, University of California, Davis “Pharmacokinetics and biocompatibility of a novel cyclosporine-loaded microsphere thermo-responsive hydrogel drug delivery system in horses”
Principal Investigator: National Institute of Health (R01) (R01 EY032222) “Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy (DR)”
Principal Investigator: National Institute of Health (R01) (R01 EY036203) “Deep Learning-based Diagnosis of Retinopathy of Prematurity"
Co-Investigator: Center for Equine Health Research Grant, University of California, Davis “Pharmacokinetics and biocompatibility of a novel cyclosporine-loaded microsphere thermo-responsive hydrogel drug delivery system in horses”
Patents and Inventions
Biodegradable microsphere-hydrogel ocular drug delivery system (Patent No 10,980,882)
Biodegradable extended release microsphere-hydrogel ocular drug delivery system and method (Patent No 11,266,608)
Biodegradable extended release microsphere-hydrogel ocular drug delivery system and method (Patent No 11,266,608)
Selected Publications
Conference Proceeding
- Vavrek, S.; Kayaalp-Nalbant, E.; Konopek, N.; Bou-Ghanem, G.; Fawzi, A.; Mieler, W.; Kang-Mieler, J.; Tichauer, K. (2023). Fluorescein videoangiography data analysis protocol for mapping retinal vascular permeability in humans. Proc SPIE (vol. 12360:123600L.).
- Kayaalp-Nalbant, E.; Annepureddy, L.; Hu, S.; Liu, W.; Tang, F.; Sun, Z.; Chung, C.; Mieler, W.; Kang-Mieler, J.; Tichauer, K. (2022). Optimizing the protocol for retinal vascular permeability mapping from fluorescein video angiography data. Proc SPIE (vol. 11941:119410K).
Journal Article
- Li, X.; Dong, Z.; Liu, H.; Kang-Mieler, J.; Ling, Y.; Gan, Y. (2023). Frequency-aware optical coherence tomography image super-resolution via conditional generative adversarial neural network. Biomedical Optics Express (vol. 14, pp. 5148-5161PMCID: PMC10370219).
- Ham, Y.; Mehta, H.; Kang-Mieler, J.; Mieler, W.; Chang, A. (2023). Novel drug delivery methods and approaches for the treatment of retinal diseases.. Asia Pac J Ophthalmol (4 ed., vol. 12, pp. 402-413).
- Yuan, B.; Rudeen, K.; Li, J.; Williams, B.; Sumughan, S.; Lopez, G.; An, H.; Kang-Mieler, J.; Chee, A. (2023). Biodegradable microspheres and hydrogel drug delivery system of tumor necrosis factor (TNF) inhibitor and growth differentiation factor 5 (GDF5) reduced disc inflammation in the rabbit model.. Spine (15 ed., vol. 48, pp. E257-E265).
- Rudeen, K. M.; Liu, W.; Mieler, W. F.; Kang-Mieler, J. J. (2022). Simultaneous Release of Aflibercept and Dexamethasone from an Ocular Drug Delivery System. . Current Eye Research (7 ed., vol. 47, pp. 1034-1042).