Translational Potential of Injectable Cellulosic Hydrogels for Soft Tissue Replacement

Tissue Engineering

Department of Biomedical Engineering

Location: EAS 212A

Speaker: Steven B. Nicoll, Ph.D Professor, Department of Biomedical Engineering, The City College of New York

Abstract

There are several indications for the use of permanent fillers for volumetric soft tissue augmentation, including the correction of localized tissue atrophy and deficits due to trauma, tumor resections, infections and congenital defects. In addition, injury and degeneration of specialized connective tissues, such as the intervertebral disc of the spinal column, require viable surgical interventions to restore function. Tissue engineering strategies may provide novel replacement therapies for such damaged or diseased soft tissues. However, there remains a need for biomaterials that are effective, biocompatible, renewable and inexpensive. Potential candidates include derivatives of the plant polysaccharide, cellulose, which may be chemically modified to create injectable, in situ gelling materials with tunable properties tailored for specific clinical applications. These hydrogels may be used alone or in combination with mesenchymal stem cells to engineer living tissue analogs. This seminar will focus on the design of these cellulosic materials, considering multiple factors such as anatomical site and FDA regulatory pathways, to guide the research and development process toward eventual clinical translation.

Biography

Steven B. Nicoll is the Director of the Connective Tissue Engineering Laboratory and Professor of Biomedical Engineering in the Grove School of Engineering at The City College of New York. Dr. Nicoll received a B.S.E in Bioengineering from the University of Pennsylvania (1994), a Ph.D. in Bioengineering from the University of California, Berkeley/San Francisco (2000), and completed a postdoctoral fellowship in Biomedical Engineering at Columbia University (2002). His research program incorporates the principles of cell and molecular biology, materials science and mechanical engineering towards the development of biohybrid constructs for connective tissue restoration. Dr. Nicoll has published over 150 journal articles, book chapters and abstracts related to connective tissue engineering, and is a reviewer for over 50 archival journals in the discipline. In addition, he has served as a Secretarial Appointee on the Department of Veterans Affairs Rehabilitation Research and Development Service Scientific Merit Review Board and on review panels for a number of other federal funding agencies and foundations in the areas of biomaterials science and translational medicine. Dr. Nicoll is an active member of several professional societies (e.g., the Society for Biomaterials, Orthopaedic Research Society), and is the recipient of multiple awards, including a National Institutes of Health Research Career Development Award (K22), a Wallace H. Coulter Foundation Early Career Translational Research Award, a National Science Foundation CAREER Award and a Harvey L. Karp Discovery Award in the Sciences.

For follow-up information to connect with speaker, contact:

Dr. George McConnell (Stevens-BME)
[email protected]

Virtual Option

Zoom Meeting ID: 728 638 6168

Passcode: BME

Attendance

Primarily for SES Graduate Students, Post Docs, and Faculty. Any interested member of Stevens community also welcome.