Brain activity is distributed over the 3-dimensional volume and evolves in time. Mapping spatio-temporal distribution of brain activation with high spatial resolution and high temporal resolution is of great importance for understanding the brain and aiding in the clinical diagnosis and management of brain disorders. Electrophysiological source imaging (ESI) from noninvasively recorded high density electroencephalogram (EEG) has played a significant role in advancing our ability to image brain function and dysfunction. We will discuss principles and current state of EEG-based ESI in localizing and imaging human brain activity with applications to imaging epileptic networks. I will also discuss our recent progress in noninvasive brain-computer interface, for controlling of a drone or robotic arm from noninvasive EEG signals using a motor imagery paradigm. Our work in a group of human subjects further demonstrate the enhanced capability in subjects with meditation/yoga training, compared with controls. Finally I will discuss transcranial focused ultrasound stimulation, as a noninvasive neuromodulation technology offering high spatial resolution and specificity, and our recent findings that ultrasound stimulation is able to induce functional cell-type specific response in in vivo brains.
Bin He is the Trustee Professor of Biomedical Engineering, Neuroscience, and by courtesy Electrical and Computer Engineering at Carnegie Mellon University. Dr. He has made significant research contributions to the fields of neuroengineering and biomedical imaging, including brain-computer interface, electrophysiological source imaging, and neuromodulation. Dr. He has received a number of awards including the IEEE Biomedical Engineering Award, the IEEE William J. Molock Award, the IEEE EMBS Academic Career Achievement Award, among others. He served as a Past President of the IEEE Engineering in Medicine and Biology Society, and serves as the Chair of the International Academy of Medical and Biological Engineering. Dr. He also served as Editor-in-Chief of IEEE Transactions on Biomedical Engineering from 2013-2018, and as Member of NIH BRAIN Initiative Multi-Council Working Group from 2014-2019. He is an elected Fellow of International Academy of Medical and Biological Engineering, IEEE, American Institute of Medical and Biological Engineering, and Biomedical Engineering Society. Dr. He is the sole editor of textbook “Neural Engineering” first published in 2005, with its 3rd edition published in fall 2020 by Springer.
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