Microfluidic systems have been used in various biochemical analysis due to the advantage of performing various analyzes in a short time with a small amount of sample. In particular, it is used for protein and DNA analysis, bio/chemical agent detection, drug delivery, etc. Recently, these microfluidic systems have been applied to develop human-on-chip or organ-on-chip for disease model development, drug response analysis, and drug development.
In this presentation, I will first introduce the various microfluidic systems developed in our laboratory for various biochemical and biological studies. After then I will introduce in vitro wound healing model developed by combining nanostructures and a microfluidic system. The growth and proliferation of cells were controlled by nanostructures and the nanostructured surfaces were integrated with a simple microchannel system to simulate wound generation and recovery in dermal skin layer. Next, I will introduce a microfluidic system that can analyze the response to external stimuli (electrical and thermal stimuli) of Caenorhabditis elegans (C. elegans). C. elegans, a prominent model organism, has interesting behavioral responses to various physical cues. We developed a straightforward microfluidic system for the analysis of electrotaxis and thermotaxis of C. elegans. Wild-type and mutant individuals showed distinctly different behavioral responses in this system which demonstrating the capability of the system for sorting.
Sun Min Kim received his B.S. and M.S. degrees in mechanical engineering from the Seoul National University, Korea, and a M.S. degree in biomedical engineering and a Ph.D. degree in mechanical engineering from the University of Michigan, Ann Arbor in 2005 and 2006, respectively. In 2007, he joined the faculty of the Department of Mechanical Engineering, Inha University, Korea, following the post-doctoral research at the Brigham and Women’s Hospital, Harvard Medical School. His research group focuses on the fundamental understanding and the development of micro/nanofluidic systems for biochemical analysis, cell-based biosensor, and organs-on-chips.
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