Complexation loading of antimicrobial peptides into microgel-modified surfaces (Jing Liang)
Chronic infection associated with tissue-contacting biomedical devices burdens patients with lots of pain and cost. Strategies need to be developed to prevent bacterial infection while promoting tissue growth on biomedical device surfaces. Here, we demonstrate an approach that first modifies a synthetic surface with anionic microgels and subsequently loads them by complexation with cationic antimicrobials. These complexed antimicrobials can be sequestered for extended time including in particular cases, for multiple weeks under physiological conditions. These modified surfaces are compatible with tissue cell proliferation.
Jing Liang joined professor Matthew Libera’s group as a Ph.D candidate in fall 2013. She received her bachelor’s degree in polymer science and engineering from East China University of Science and Technology.
Shear viscosity and apparent slip of non-colloidal polydisperse suspensions (Jing He)
A silicone polymer was incorporated with polydisperse particles with low aspect ratios to achieve a high maximum packing fraction, ϕm=0.86. Such high ϕm allowed the preparation of well-mixed suspensions with a wide range of solid volume fractions, ϕ, i.e., 0.62 ≤ ϕ ≤ 0.82. It is demonstrated that the characterization of the relative shear viscosity of dense suspensions necessitates wall slip analysis, and such analysis is simplified by the understanding that the mechanism of slip for dense suspensions is governed by apparent slip layer formation at the wall.
Jing He is pursuing his Ph.D under the supervision of professors Dilhan Kalyon and Stephanie Lee (co-advisor). His research focuses on the rheology of complex fluids involved in fire retardant and alternative energy applications. He received his B.E. degree in polymer engineering from South China University of Technology.