Bioengineering

Bioengineering

The Biomedical Engineering research initiatives in the Mechanical Engineering Department at Stevens enables the students to integrate the life sciences with the traditional mechanical engineering topics of solid mechanics, dynamics, fluid mechanics, thermodynamics, heat transfer, materials, robotics and control systems to analysis, and to solve problems related to biomechanical engineering, biotechnology and medicine. Various principles of Mechanical Engineering are applied to address research questions in the emerging areas of tissue engineering, cell mechanobiology, drug delivery, implant design, non-invasive tissue assessment, microscale physiological/disease platform design, multiscale tissue biomechanics and disease predictive modeling among others. The focus of our research is on the (experimental and computational) biomodeling of three-dimensional tissues and implantable devices, along with biomeasurements (primarily optical imaging modalities).

Current research activities include:

  • Design, modeling and fabrication of microscale tissue scaffolds for the investigation of cell-scaffold dimensional metrology
  • Hyperspectral imaging acquisition and processing for burn evaluation and assessment
  • Development of an optical tissue phantom as calibration standard for depth-resolved imaging systems (e.g. OCT and confocal imaging)
  • Development of an electromagnetic device for enhanced osteointegration
  • Multiphysics structural modeling of collective tympanic membrane epithelial migration for the pathophysiology of cholesteatomas
  • 3D bioprinting of thermosensitive hydrogels
  • Bioreactor design of scaled-up stem cell culture systems
  • Development of a shear strain device for modeling traumatic brain injury
  • Development of multiphysics, multiscale computational models of arterial pulsation analysis with applications to disease diagnosis and treatment monitoring of patients with aortic aneurysm, stenosis, stent graft
  • Optimization of stent graft performance using pulse wave analysis and innovative stent design
  • Development of computational and experimental set up to characterize the damage initiation and propagation mechanisms in patients with aortic aneurysm or aortic dissection
  • Development of multifaceted decision making infrastructure to enhance cardiovascular and other disease diagnosis
  • Development of highly multiphysics computational models as well as experimental set up to examine the use of radiation-based diagnosis and treatment for pathological conditions such as soft tissue tumors and aortic plaques

Given the interdisciplinary nature of bioengineering study, the research undertaken in our department has been characterized by strong collaborations with research groups within the department, with other departments, other universities as well as collaborations with government (NIST, FDA) and clinical collaborators at Hackensack University Medical Center and UMDNJ New Jersey Medical School.

Areas of Expertise:
  • 3D bioprinting cell-embedded biopolymers
  • Hyperspectral imaging acquisition and analysis
  • Combinatorial materials approach for optical phantom development
  • Multiphysics structural cell-based modeling
  • Computational modeling of multiphysics, multiscale disease development
  • Computational modeling of medical devices
  • Constitutive modeling of anisotropic, inhomogeneous, viscoelastic, nonlinear, porous soft tissues
  • Soft tissue histological examination
  • Experimental characterization of soft tissues structural and mechanical properties using MTS, Instron, AFM, Ultrasound and other imaging modalities, DIC, Vicon
Research Examples:

Sensitivity of the Fourier–Hough method with respect to (a) and (b) histology image unalignment, (c) histology image thresholding, and (d) Fourier image thresholding. Four representative histology images were selected: (1) native, inner thickness, no-loaded, (2) native, inner thickness, under stretch 2.0, (3) elastin-isolated, outer thickness, under stretch 1.4, (4) elastin-isolated, inner thickness, recovered from stretch 1.4. The blue-shaded regions in (c) and (d) indicate a proper thresholding range. (Shahmirzadi et al, IEEE Trans. Biomedical Engineering, 60(5), 2013)

Technical Electives:
  • ME 525 Biomechanics
  • ME 526 Biofluid Mechanics
  • ME 527 Mechanics of Human Movement
  • ME 528 Physiological Systems (for Engineers)
  • ME 580 Medical Device Design and Technology
  • ME 581 Introduction to Bio Micro Electro Mechanical Systems (BioMEMS)
  • ME 660 Medical Devices Manufacturing
  • ME 690 Cell Mechanics
  • ME 691 Computer-Aided Tissue Engineering
Research Laboratories:
Related Faculty


Dr. Robert Chang
Assistant Professor


Dr. Sven Esche
Associate Professor, Associate Department Director, and Director of Graduate Programs


Dr. Yazan Manna
Teaching Assistant Professor


Dr. Danial Shahmirzadi
Visiting Assistant Professor


Dr. Yong Shi
Associate Professor


Dr. Eui-Hyeok Yang
Associate Professor