- ME 644 Computer-Integrated Design and Manufacturing
Fundamentals of Computer-Integrated Design and Manufacturing addresses design and manufacturing as a global closed-loop system comprising four major functions: marketing, part design, process specifications and production. The emphasis of this course is on the computer integration of the islands of automation created by isolated computerized systems within these major functions in an enterprise. - ME 645 Design of Production Systems
Introduction to the design and control of production systems using mathematical, computational and other modern techniques. Topics that will be investigated include forecasting, inventory systems, aggregate production planning, material requirements planning, project planning, job sequencing, operations scheduling and reliability, in addition to capacity, flexibility and economic analysis of flexible manufacturing systems. - ME 652 Advanced Manufacturing
This course is intended to give the student an in-depth appreciation of contemporary and emerging manufacturing methods in use in a wide variety of durable and consumable goods industries. The initial emphasis will be on the mechanics of material removal/material flows and processing. Next, contemporary net-shape composite manufacturing processing techniques, equipment and testing methods will be presented and demonstrated whenever possible. The course will conclude with hands-on manufacturing projects accomplished in teams, focusing on the study of the field of manufacturing processes from a mechanical engineering design standpoint. Topics will include optimum mechanical design for cost, weight, stress, energy and tolerances. - ME 665 Advanced Product Development
This course addresses methodologies and tools to define product development phases and also provides experience working in teams to design high-quality competitive products. Primary goals are to improve ability to reason about design, material and process alternatives and apply modeling techniques appropriate for different development phases, as well as development of competitive product design and plans for its manufacture along with facilities layout simulation, testing and service. Topics covered are: user requirements gathering, quality function deployment (QFD), design for assembly, design for materials and manufacturing processes, optimizing the design for cost and producibility, manufacturing process specifications and planning, process control and optimization, SPC and six sigma process, tolerance analysis, flexible manufacturing, product testing and rapid prototyping.
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- ME 535 Good Manufacturing Practice in Pharmaceutical Facilities Design
Current Good Manufacturing Practice compliance issues in design of pharmaceutical and biopharmaceutical facilities. Issues related to process flow, material flow, and people flow, and A&E mechanical, industrial, HVAC, automation, electrical, and computer. Bio-safety levels. Developing effective written procedures, so that proper documentation can be provided, and then documenting through validation that processes with a high degree of assurance do what they are intended to do. Levels I, II, and III policies. Clinical phases I, II, III and their effect on plant design. Defending products against contamination. Building quality into products. - ME 540 Validation and Regulatory Affairs in Pharmeceutical Manufacturing
Validation of a pharmaceutical manufacturing process is an essential requirement with respect to compliance with Good Manufacturing Practices (GMP) contained within the Code of Federal Regulations (21 CFR). Course covers validation concepts for plant, process, cleaning, sterilization, filtration, analytical methods, and computer systems; GAMP (Good Automated Manufacturing Practice), IEEE SQAP, and new electronic requirements - 21 CFR Part 11. Master validation plan, IQ, OQ, and PQ protocols, and relationships to GMP. National (FDA) and international (EU) regulatory affairs for cGMP (current Good Manufacturing Practice) and cGLP (current Good Laboratory Practice) requirements in development, manufacturing, and marketing. Handling the FDA inspection. - ME 628 Manufacturing and Packaging of Pharmaceutical Oral Solid Dosage Products
The course covers oral solid dosage (OSD) manufacturing and packaging in the pharmaceutical industry. Production unit operations include blending, granulation, size reduction, drying, compressing, and coating for tablets, as well as capsule filling. Packaging aspects reviewed include requirements for primary and secondary containers and labeling, package testing. The course emphasizes design, scale-up, trouble-shooting, validation, and operation of typical OSD manufacturing and packaging facilities, including equipment, material flow, utilities, and quality assurance. Topics related to cGMP, process validation, manufacturing and packaging documentation, QA and QC in OSD manufacturing will be presented. The term project required for this course involves conceptual design of a contract manufacturing and packaging facility for OSD products, including equipment selection, development of the process flow diagrams, room layouts and other design elements, as well as preparation of Standard Operating Procedures for various unit operations. - ME 645 Design of Production Systems
Introduction to the design and control of production systems using mathematical, computational and other modern techniques. Topics that will be investigated include forecasting, inventory systems, aggregate production planning, material requirements planning, project planning, job sequencing, operations scheduling and reliability, in addition to capacity, flexibility and economic analysis of flexible manufacturing systems.
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- ME 615 Thermal Systems Design
Introduction to fluid mechanics and heat transfer; design of piping systems; selection of pumps; analysis and design of heat exchangers; modeling and simulation of thermal systems; system optimization and design; case studies.
- ME 644 Computer-Integrated Design and Manufacturing
Fundamentals of Computer-Integrated Design and Manufacturing addresses design and manufacturing as a global closed-loop system comprising four major functions: marketing, part design, process specifications and production. The emphasis of this course is on the computer integration of the islands of automation created by isolated computerized systems within these major functions in an enterprise. - ME 659 Advanced Structural Design
This course deals with methodologies for designing modern structures and other performance-driven products. The course entails aspects of computer-aided engineering (CAE), integration of CAE and design, methodologies for failure and stability analysis, designing with anisotropic materials such as composites, modeling process-material-performance relationships and the use of such models in design, multidisciplinary design optimization and integrated product design automation. - ME 665 Advanced Product Development
This course addresses methodologies and tools to define product development phases and also provides experience working in teams to design high-quality competitive products. Primary goals are to improve ability to reason about design, material and process alternatives and apply modeling techniques appropriate for different development phases, as well as development of competitive product design and plans for its manufacture along with facilities layout simulation, testing and service. Topics covered are: user requirements gathering, quality function deployment (QFD), design for assembly, design for materials and manufacturing processes, optimizing the design for cost and producibility, manufacturing process specifications and planning, process control and optimization, SPC and six sigma process, tolerance analysis, flexible manufacturing, product testing and rapid prototyping.
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- ME 601 Engineering Thermodynamics
Fundamental laws of the thermodynamics of mechanical, thermal and chemical equilibrium systems; thermodynamic properties of materials including multiphase, multicomponent systems with gaseous chemical reactions; analysis of thermodynamic systems (open and closed) based primarily on the first and second laws. - ME 604 Advanced Heat Transfer
Fundamental modes of heat transfer; conduction, thermal resistance, extended surface with variable cross-section area, application of analytical, numerical and analog methods to the steady and unsteady state; convection, fluid flow and elementary boundary layer theory, dimensional analysis, forced convection for internal and external flows, natural convection, laminar and turbulent flow correlation formulas, condensation and boiling; radiation, physical foundations, radiative properties of surfaces, enclosure radiation, view factors, electrical analogy, gas radiation. - ME 615 Thermal Systems Design
Introduction to fluid mechanics and heat transfer; design of piping systems; selection of pumps; analysis and design of heat exchangers; modeling and simulation of thermal systems; system optimization and design; case studies.
- ME 674 Fluid Dynamics
Stress in a continuum; kinematics of fluid motion; rate of strain and vorticity; relation between stress and rate of strain; the Navier-Stokes equations; inviscid flow; stream function, velocity potential and circulation; Kelvin and Helmholtz theorems; two-dimensional incompressible flows; the Kuta-Joukowski theorem; introduction to compressible flows, boundary layers and drag-on bodies.
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