PME 530:Introduction to Pharmaceutical Manufacturing
Pharmaceutical manufacturing is vital to the success of the technical operations of a pharmaceutical company. This course is approached from the need to balance company economic considerations with the regulatory compliance requirements of safety, effectiveness, identity, strength, quality, and purity of the products manufactured for distribution and sale by the company. Overview of chemical and biotech process technology and equipment; dosage forms and finishing systems; facility engineering; health, safety, and environment concepts; and regulatory issues.
PME 535:Good Manufacturing Practice in Pharmaceutical Facilities Design
Current Good Manufacturing Practice compliance issues in design of pharmaceutical and biopharmaceutical facilities; issues related to process flow, material flow and people flow, and A&E mechanical, industrial, HVAC, automation, electrical, and computer; bio-safety levels; developing effective written procedures so that proper documentation can be provided, and then documenting through validation that processes with a high degree of assurance do what they are intended to do; levels I, II, and III policies; clinical phases I, II, and III, and their effect on plant design; defending products against contamination; and building quality into products.
PME 540:Validation and Regulatory Affairs in Pharmaceutical Manufacturing
An introduction to validation concepts in plant, process, clean-up, sterilization, filtration, analytical methods, and computer systems. Learn about Good Automated Manufacturing Practice (GAMP), IEEESQAP, and new electronic requirements, such as 21 CFR Part 11. Explore master validation plans, IQ, OQ, and PQ protocols, and their relationships to GMP. Become familiar with FDA and international (EU) regulations governing current Good Manufacturing Practices (cGMP) and current Good Laboratory Practices (cGLP).
PME 539:Bioprocess Technology in API Manufacturing
This course provides a broad overview of topics related to the design and operations of modern biopharmaceutical facilities. It covers process, utilities, and facility design issues, and encompasses all major manufacturing areas, such as fermentation, harvest, primary and final purification, media and buffer preparation, equipment cleaning and sterilization, and critical process utilities. Unit operations include cell culture, centrifugation, conventional and tangential flow filtration, chromatography, solution preparation, and bulk filling. Application of current Good Manufacturing Practices and Bioprocessing Equipment Standards (BPE-2002) will be discussed.
PME 628:Pharmaceutical Finishing and Packaging System – Solid Dosage
The course covers finished product manufacturing and packaging systems in the pharmaceutical industry, concentrating on the oral solid dosage forms. Process unit operations include blending, granulating, size reduction, drying, compressing, and coating for tablets, as well as blending and filling for capsules. The design and operation of packaging equipment for tablet and capsule counting, capping, security sealing, labeling, cartoning, and case packing will be considered. An approach for the development of project documentation, such as equipment specifications, purchase orders, test plans, and validation documents will be presented. The use of computer simulation tools for system development and improvement will be discussed. A term paper project will require students to collectively design a solid dosage manufacturing and packaging facility, considering selection of processing and packaging equipment, material flow, development of commissioning and qualification plan and protocols.
PME 639:Modeling and Simulation of Pharmaceutical Manufacturing Systems
This course will introduce students to modeling and simulation applications in pharmaceutical manufacturing. The fundamentals of discrete event simulation and the use of commercially available software to develop models of various manufacturing and service systems will be introduced. Approaches to the development of conceptual and computer models, data collection and analysis, model verification and validation, and simulation output analysis will be discussed. The modeling of chemical, biochemical and separation processes in pharmaceutical manufacturing using process simulation software will be presented. Material balances, stream reports, operations and equipment Gantt charts will be developed and process debottlenecking and cost analysis will be conducted.
Research & Education
Education
Ph.D. in Chemical Engineering, College of Technology, Moscow Russia
B.S. in Mechanical/Electrical Engineering, Engineering college, Moscow Russia
Experience & Service
General Information
Leonid Shnayder, PhD, P.E., is an Industry Professor of Mechanical Engineering – Pharmaceutical Manufacturing Program at Stevens. Being a Registered Professional Engineer, he worked for fourteen years as a Process Manager and Principal Process Engineer for major engineering companies serving pharmaceutical manufacturing market. His areas of expertise include finished pharmaceutical manufacturing, biotechnological processes, Clean-In-Place and clean process utilities (Pure Steam, Water-for-Injection, USP Purified Water etc.). He was responsible for the process design of biotech facilities for Amgen, Wyeth, ImClone, finished pharmaceutical facilities for Merck, Boehringer Ingelheim, Wyeth-Lederle and others. Prior to that he worked as a Research Scientist / Process Development with national pharmaceutical company in Russia, where he was involved in the development and optimization of various fermentation processes, including biosynthesis of penicillin, oxytetracycline and other antibiotics.
Achievements & Professional Societies
Professional Societies
International Society for Pharmaceutical Engineering (ISPE) – Member; Industry Advisor to Stevens’ Student Chapter of ISPE; Member of Student Affairs Committee of the NJ Chapter.
Patents & Inventions
Author of eight patents in the field of pharmaceutical manufacturing technology.
Selected Publications
Journals
L. Shnayder, M. Khanina. (2005). "Equipment Cleaning-In-Place in Modern Biopharmaceutical Facilities: Engineering Concepts and Challenges", Pharmaceutical Engineering, 25 (1).
L.Shnayder. (2001). "Pharmaceutical Purified Water Storage and Distribution Systems - an Engineering Prospective", Pharmaceutical Engineering, 21 (6).
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