Interpretation of infrared, ultraviolet, nuclear magnetic resonance, and mass spectra. Emphasis is on the use of these spectroscopic methods in identification and structure determination of organic compounds.
Experimental approach to spectroscopy. Topics include Fourier Transform infrared spectroscopy, ultraviolet, visible and fluorescence measurements, atomic absorption spectroscopy, and nuclear magnetic resonance spectroscopy.
Chemical kinetics, solution theories with applications to separation processes, electrolytes, polyelectrolytes, regular solutions and phase equilibria, and laboratory practice in the measurements of physical properties and rate processes.
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
Introduces the essentials of probability theory and elementary statistics. Lectures and assignments greatly stress the manifold applications of probability and statistics to computer science, production management, quality control, and reliability. A statistical computer package is used throughout the course for teaching and for assignments. Contents include: descriptive statistics, pictorial and tabular methods, and measures of location and of variability; sample space and events, probability axioms, and counting techniques; conditional probability and independence, and Bayes' formula; discrete random variables, distribution functions and moments, and binomial and Poisson distributions; continuous random variables, densities and moments, normal, gamma, and exponential and Weibull distributions unions; distribution of the sum and average of random samples; the Central Limit Theorem; confidence intervals for the mean and the variance; hypothesis testing and p-values, and applications for the mean; simple linear regression, and estimation of and inference about the parameters; and correlation and prediction in a regression model.
Simple harmonic motion, oscillations and pendulums; Fourier analysis; wave properties; wave-particle dualism; the Schrödinger equation and its interpretation; wave functions; the Heisenberg uncertainty principle; quantum mechanical tunneling and application; quantum mechanics of a particle in a "box," the hydrogen atom; electronic spin; properties of many electron atoms; atomic spectra; principles of lasers and applications; electrons in solids; conductors and semiconductors; the n-p junction and the transistor; properties of atomic nuclei; radioactivity; fusion and fission. Spring Semester.
Theory and practice of analytical chemistry. Topics include sampling techniques, potentiometric and conductometric titrations, chromatographic separations (gas and high-performance liquid chromatography), polarimetry, and gas chromatography-mass spectrometry.
Discussions include metabolic pathways in biosynthesis and catabolism of biomolecules, including carbohydrates, proteins, lipids, and nucleic acids. The hormonal regulation of metabolism, as well as vitamin metabolism, is presented.
The behavior of and interactions between individual participants in the economic system are covered. In addition to providing a theoretical basis for the analysis of these economic questions, the course also develops applications of these theories to a number of current problems. Topics include: the nature of economic decisions, the theory of market processes, models of imperfect competition, public policy towards competition, and the allocation of factors of production.
An advanced course applying principles and theory to problems in chemical analysis. Theory of separations, including distillation, chromatography, and ultracentrifugation; heterogeneity and surface effects; and sampling and its problems.
A comprehensive hands-on course covering both fundamentals and modern aspects of mass spectrometry, with emphasis on biological and biochemical applications. Topics include: contemporary methods of gas phase ion formation [electron ionization (EI), chemical ionization (CI), inductively coupled plasma (ICP), fast atom bombardment (FAB), plasma desorption (PD), electrospray (ESI), atmospheric pressure chemical ionization (APCI), matrix assisted laser desorption ionization (MALDI), detection (electron and photomultipliers, and array detectors), and mass analysis [magnetic deflection, quadrupole, ion trap, time of flight (TOF), and Fourier-transform (FTMS)]. Detailed interpretation of organic mass spectra for structural information, with special emphasis on even-electron-ion fragmentation. Qualitative and quantitative applications in environmental, biological, pharmacological, forensic, and geochemical sciences.
Participation in a small group project, under the guidance of a faculty member, whose prior approval is required. Experimentation, application of chemical knowledge and developmental research leading to the implementation of a working chemical process. Individual or group written report required. Open to juniors and seniors only.
Individual research project under the guidance of a chemistry faculty member, whose prior approval is required. A written report in acceptable journal format and an oral presentation are required at the end of the project. Senior students only. Ch 498 and Ch 499 cannot be taken simultaneously.
Advanced treatment of the theory and practice of spectrometric methods (mass spectrometry, nuclear magnetic resonance, etc.) and electroanalytical methods with emphasis on Fourier Transform techniques (FTIR, FTNMR, etc.) and hyphenated methods (gc-ms, etc.), the instrument-sample interaction, and signal sampling. A survey of computational methods, such as factor analysis and other chemometric methods is also included.
Lecture and laboratory; ionic solids, lattice energy, and factors determining solubility; thermodynamics in inorganic synthesis and analysis; acid-base equilibria; and systematic chemistry of the halogens and other non-metals.
The relationship of the chemical and physical structure of biological macromolecules to their biological functions as derived from osmotic pressure, viscosity, light and X-ray scatting, diffusion, ultracentrifugation, and electrophoresis. The course is subdivided into: 1) properties, functions, and interrelations of biological macromolecules, e.g., polysaccharides, proteins, and nucleic acids; 2) correlation of physical properties of macromolecules in solution; 3) conformational properties of proteins and nucleic acids; and 4) aspects of metal ions in biological systems.
Participation in a small group project, under the guidance of a faculty member, whose prior approval is required. Experimentation, application of chemical knowledge and developmental research leading to the implementation of a working chemical process. Individual or group written report required. Open to juniors and seniors only.
Individual research project under the guidance of a chemistry faculty member, whose prior approval is required. A written report in acceptable journal format and an oral presentation are required at the end of the project. Senior students only. Ch 498 and Ch 499 cannot be taken simultaneously.
0
8
4
3
Total
12
12
24
16
(1)
Requires advisor' approval.
(2)
Project/Research can be either a project (CH 496/497) or thesis (CH 498/499) and can be done either in the junior/senior year or senior year.
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