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Graduate Courses

Biomedical Engineering   Chemistry & Chemical Biology   Nanotechnology   BME 503 Physiological Systems Close Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis. BME 504  / CPE 585  Medical Instrumentation and Imaging Close Imaging plays a critical role in both clinical and research environments. This course presents both the basic physics and the practical technology associated with such methods as X-ray computed tomography (CT), magnetic resonance imaging (MRI), functional MRI (f-MRI) and spectroscopy, ultrasonics (echocardiography, doppler flow), nuclear medicine (Gallium, PET and SPECT scans) and optical methods such as bioluminescence, optical tomography, fluorescent confocal microscopy, two-photon microscopy and atomic force microscopy. BME 505  / MT 505  Biomaterials Close Intended as an introduction to materials science for biomedical engineers, this course first reviews the properties of materials relevant to their application to the human body. It goes on to discuss proteins, cells, tissues and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs and elements of tissue engineering. BME 506 Biomechanics Close This course reviews basic engineering principles governing materials and structures such as mechanics, rigid body dynamics, fluid mechanics and solid mechanics and applies these to the study of biological systems such as ligaments, tendons, bone, muscles, joints, etc. The influence of material properties on the structure and function of organisms provides an appreciation for the mechanical complexity of biological systems. Methods for both rigid body and deformational mechanics are developed in the context of bone, muscle and connective tissue. Multiple applications of Newton's Laws of Mechanics are made to human motion. BME 557 Sensory Systems Close Course focuses on speech, audition, and vision systems. Students will begin with a review of system principles including sampling, filtering, analog to digital conversion (ADC), spectral (Fourier) analysis and transfer functions. The second topic will cover the audio spectrum and properties of sound as they relate to both speech and hearing. The course will then cover basic anatomy and physiology of the larynx, ear, and eye. Students will participate in two types of Labs for each of the three topics. Sensory Labs are designed to enhance the students’ knowledge of sound production, auditory response and image processing. Reverse Engineering (RE) Labs utilizing existing speech, hearing, and vision enhancement products will be conducted as well. BME 600 Strategies and Principles of Biomedical Design Close A successful approach to product development and design in the field of medical technologies requires a highly interdisciplinary approach. This course reviews the regulations, protocol, and guidelines which must be met in each discipline, and describes how these issues are inter-related and how they affect design and product development. Marketing, regulatory, IP, and clinical aspects are all considered in the technical aspects of design. Required of all BME M.E. students. BME 601 Advanced Biomedical Engineering Lab Close One of the distinguishing features of biomedical engineers is the ability to make and interpret measurements on living systems. One of the major objectives of advanced laboratory training is to provide experience in selecting appropriate measurement and analysis tools that will advance hypothesis driven and translational research and development. This laboratory course serves these dual purposes. Students are introduced to techniques for measurements at the cellular, organ and systems levels. Students will then use these techniques to: (1) formulate hypotheses, design experiments using the tools provided, make appropriate measurements, analyze the data and determine if the data do or do not support their hypotheses and (2) make measurements that facilitate the design and manufacture of devices in terms of materials properties, fatigue and failure modes. BME 602  / NANO 602  Principles of Tissue Engineering Close This course is an introduction to the field of Tissue Engineering. It is rapidly emerging as a therapeutic approach to treating damaged or diseased tissues in the biotechnology industry. In essence, new and functional living tissue can be fabricated using living cells combined with a scaffolding material to guide tissue development. Such scaffolds can be synthetic, natural, or a combination of both. This course will cover the advances in the field of cell biology, molecular biology, material science, and their relationship towards developing novel ‘tissue engineered’ materials. BME 603 Topics in Biological Transport Close The engineering applications of biological transport phenomena are important considerations in basic research related to molecules, organelles, cell, and organ function; the design and operation of devices such as filtration units for kidney dialysis, high density cell cultures, and biosensors; and applications including drug and gene delivery, biological signal transduction, and tissue engineering. This course develops the fundamental principles of transport processes, the mathematical expression of these principles and the solution of transport equations, along with characterization of composition, structure, and function of the living systems to which they are applied. BME 650  / NANO 650  Advanced Biomaterials Close Upon completion of this course, students will be able to demonstrate an understanding of the major classes of engineering materials, their principal properties, and design requirements that serve as both the basis for materials selection, as well as for the ongoing development of new materials. This course is substantially differentiated from introductory materials courses by its very specific focus on materials whose use puts them in direct contact with physiological systems. Thus, the course begins with brief sections on inflammatory response, thrombosis, infection, and device failure. It then concentrates on developing the fundamental materials science and engineering concepts underlying the structure-property relationships in both synthetic and natural polymers, metals and alloys, and ceramics relevant to in vivo medical device technology. BME 655 Principles of Multiscale Biosystems Development and Integration Close This course extends concepts presented in tissue engineering, bio-transport, and biomaterials to develop design principles for generating tissue and organs in vitro. The processes by which cells, proteins, and extracellular matrix are integrated to form a functioning organ system are developed. The principles of bioreactor design are used to analyze and design in vitro systems for growing functioning tissue and organs for use as prostheses. Principles for scale-up to organs of different size are discussed. Design issues and limitations for extension of these principles to multi-organ systems are illustrated. BME 665 Pathophysiology Close Pathophysiology describes changes in physiology resulting in disease or injury. A solid understanding of normal physiology is necessary before attempting the study of abnormal situations. The course emphasizes the “mechanistic” approach to pathophysiology, i.e. A-B-C, rather than symptom-diagnosis-treatment approach. Multiple examples, case studies, and procedural videos are presented with a discussion of what they do well and where improvements can be made. BME 675  / NANO 675  Nanomedicine Close This course will provide a comprehensive introduction to the rapidly developing field of nanomedicine and discuss the application of nanoscience and nanotechnology in medicine such as, in diagnosis, imaging and therapy, surgery, and drug delivery. BME 685  / NANO 685  Nanobiotechnology Close This course describes the application of nano- and micro-fabrication methods to build tools for exploring the mysteries of biological systems. It is a graduate-level course that will cover the basics of biology and the principles and practice of nano- and microfabrication techniques, with a focus on applications in biomedical and biological research. BME 690  / CH 690  Cellular Signal Transduction Close This advanced course covers the mechanism and biological role of signal transduction in mammalian cells. Topics included are extracellular regulatory signals, intracellular signal transduction pathways, role of tissue context in the function of cellular regulation, and examples of biological processes controlled by specific cellular signal transduction pathways. BME 695  / ChE 695  Bio/Nano Photonics Close This course deals with the principles of light interactions with biological- and biomedical-relevant systems. The enabling aspects of nanotechnology for advanced biosensing, medical diagnosis, and therapeutically treatment will be discussed. BME 700 Seminar in Biomedical Engineering Close Lectures by department faculty, guest speakers. and doctoral students on recent research. Enrollment during the entire period of study is required of all full-time students. No credit. Must be taken every semester. BME 701-702 Selected Topics in Biomedical Engineering I-II Close Selected topics of current interest in the field of biomedical engineering will be treated from an advanced point of view. BME 800 Special Problems in Biomedical Engineering Close One to three credits. Limit of three credits for the degree of Master of Engineering (Biomedical). BME 900 Masters Thesis in Biomedical Engineering Close For the degree of Master of Engineering (Biomedical). Nine credits with departmental approval BME 950 Biomedical Engineering Design Project Close Design project for the degree of Master of Engineering (Biomedical). Hours to be arranged. Six credits, with departmental approval. BME 960 Dissertation in Biomedical Engineering Close Original research leading to the doctoral dissertation. Hours and credits to be arranged.