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| Modern Mass Spectrometry: Chemistry 666 | |
| Lecture and Practical Schedule |
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Aug 31st | Course Introduction; Review of spectroscopic techniques; basic concepts of MS; Detectors, Analyzers (magnetic, quadrupole, ion trap, TOF, FTMS), ionization Techniques (EI, CI, DCI, FD, ICP, FAB) | Sept 7th | Ionization Techniques (ESI, turbospray, nanospray, sonic-spray, photo-ionization, APCI, MALDI, SELDI) | Sept 14th | Data Acquisition, Elemental composition, accurate mass (lockspray), isotopes, molecular ion, molecular formulas, degree of unsaturation, "Rule of 13" | Sept 21st | Basic fragmentation mechanisms, electron-ionization (EI) spectra, Interpretation of EI spectra: Hydrocarbons, alcohols and phenols, ethers, aldehydes, ketones, acids, esters, amines and amides. | Sep 28th | Continuation EI spectra | Oct 5th | Multiply charged ions, mol wt. of proteins, CAD, MS/MS, linked scans | Oct 12th | Preliminary Exam 1 | Oct 19th | Fragmentation of even-electron positive and negative ions | Oct 26th | Amino acids and other small molecules, peptide sequencing, proteins | Nov 2nd | Carbohydrates, nucleosides, oligonucleotides, lipids | Nov 9th | GC-MS, derivatization, artifacts, computer identification of spectra (PBM), use of Wiley Library | Nov 16th | Guest Lecture ? | Nov 23rd | Thanksgiving Recess, no class | Nov 30th | LC-MS, quantification Application of Mass Spectrometry (Environmental, Biological, Pharmacological, Forensic, Geochemical Applications), IRMS | Dec 7th | Review session. "Why Mass Spectrometry is so difficult to understand" (each student will be given an article from literature to review; 25 bonus points). | Dec 14th | Final Exam | | Books |
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| Mass Spectrometry
A Textbook
Gross, Jürgen H. 2004, XVIII, 518 p. 357 illus., Hardcover
ISBN: 3-540-40739-1 | | INTERPRETATION OFMASS SPECTRA4TH EDITION
Fred W. McLafferty
Cornell University
Frantisek Turecek
University of Washington | | Practical Schedule |
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Five Saturday sessions will be held between 9 AM-12 noon. Dates will be announced later. | | Chemistry 666 | Fall 2006 |
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| | | | Grading Scheme (Total 500 pts) |
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(All quizzes will be take-home. They will be handed out before the class and due on the following week) | Quiz #1 | (Sept 7; due Sept 14) | 30 pts | Quiz #2 | (Sept 21; due Sept 28) | 30 pts | Quiz #3 | (Oct 12; due Oct 19) | 30 pts | Quiz #4 | (Oct 26; due Nov 2) | 30 pts | Quiz #5 | (Nov 9; due Nov 16) | 30 pts | | Prelim #1 | (Oct 12, Thursday 6.30 - 9.00 PM) | 150 pts | | Review session #1 | (Dec 8, Thursday 6.15 - 9.00 PM) | (25 bonus points) | | Final Exam | Dec 14, 6.15-9.00 PM open book | 200 pts | | | Total | 500 pts |
“Prof. Attygalle is an excellent instructor. He is very good about presenting nuanced concepts by pointing to what is important to know”
Ian Knemeyer, Schering Plough Corp, Fall 2003
“ Dr. Attygalle delivers organized and clear lectures in class. Though the class is not easy, I look forward to the challenges Dr. Attygalle presents in class. The majority of the material that Dr. Attygalle covers, cannot be found in other sources”
Deborah L. Shanks, Fall 2003
“ This course was a very good introduction into modern methods of Mass Spec. We covered a lot of topics in a short amount of time. I think I have a good feel for what types of mass spectrometry are available and what techniques can be used to detect certain molecules as well as derive structural information. I think the take home quizzes provided helpful practice in practical problem solving. The content of the course was very up-to-date and provided analysis of relevant molecules in today's biochemical/Pharmaceutical applications. The handouts were very helpful, I can't imagine trying to write everything down. The in-class animations were well prepared and provided a useful demonstration ”
David Merkooloff,Wyeth, Fall 2004
“ Overall, I feel that this course was extremely helpful to my understanding of MS analysis. The concepts were delivered in a clear, concise, and best of all, an entertaining manner. I thoroughly enjoyed attending the lectures”
Carol Dragland, Novartis Pharmaceutical Corp, Fall 2003
“ I would highly recommend this course to anyone who likes to independently run a MS and interpret the results”
Mirlinda Biba, Merck Phamaceuticals
“It’s been a long time since I took such a useful course in chemistry”
Julius Pavlv, Nicoll Lab, Fall 2002
“ This course well met beyond my expectations. Every lecture covered an extremely important aspect of mass spectrometry in one form or another. The instructor was able to captivate the essential features in every mass spectrometric technique and application. For example, the lab classes provided hand on experience that facilitated learning of the different types of mass spectrometers. Also, learning how to critique usage of mass spectrometric terms helped develop a better understanding of accurate definitions and more concise writing.
I have attended many mass spectrometry seminars and short courses. When compared with the widely publicized ACS short course for introduction to mass spectrometry, this course is no comparison. The ACS short course only provides an introduction that leaves you with knowing that mass spectrometry is a diverse topic. After completing the ACS short course, you don’t leave with necessary tools to further learn. The Modern Mass Spectrometry course at Stevens Institute of Technology teaches the fundamentals and ensures that you leave the course with the knowledge to learn further”
Simman Wong, Pfizer, Inc., Fall 2002
“The course will be very helpful for my job, because I am doing drug metabolite identification using LC/MS/MS.” “I would like to tell you that the class, Modern mass spectrometer, is very very helpful for my job, identification of drug metabolites. Before I did not know why and where the molecule should be broken when we run MSMS. Also I didn’t know how and why my supervisor drawn the fragment structure and charge site like that. Right now I understand all of them, I am very happy I did right thing to take this class”
Jiansheng Huang, Hoffmann-La Roche
“ I am very glad that I attended this course. As an analytical chemist I found this course very useful in providing up to date knowledge of mass spectrometry theory and techniques. The “Even Electron Fragmentation Mechanism” which is the core of Electrospray, MAldI, and FAB MS couldn’t be found in any published text book. The professor with strong experience and background of the subjects provided an excellent visual and animation materials and slides which helped in delivering the concepts more easily”
Najeh Kharbatia, ISP Corp, Fall 2003
“ A real graduate-level course which helped me to enhance all my skills”
Sheetal S. Rao, Fall 2002
“ ..it is a fast paced course covering tons of material.. ”
Demis Ros, 2005
“ Without an extremely strong background in organic chemistry, nor previous experience with MS, I was able to follow and apply most of the subject area we covered ”
Gretel Raibeck, US Army, 2005
“ I am glad to have taken this course because I am able to converse with PhD's at work and fully understand their explanations ”
Brian Tiu, Schering Plough Corp, 2005
“ The course was excellent. Anyone considering a carrier in Organic or analytical chemistry should definitely take this course ”
Chris Westergon, Ethicon Inc., 2005
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Download the 2008 Modern Mass Spectrometry Course PDF (13KB)
How to enroll as a non-matriculating student (29KB) Athula Attygalle
Research Professor, Chemistry
McLean Chemical Sciences Building
Room 312
Phone: 201.216.5575
Fax: 201.216.8240
aattygal@stevens.edu |
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