CHE 501 Mass and Energy Balances, Stagewise OperationsClose
This course serves as an introduction to chemical engineering for those with no previous training in the field. Among the topics covered are mass and energy balances, and equilibrium stagewise operations. |
|
CHE 502 Transport PhenomenaClose
This introductory course in chemical engineering covers mass, heat and momentum transfer. |
|
CHE 504 Safety of Pilot Plants and Research OperationsClose
This course is intended to teach the basis of safety in pilot plants, laboratory and similar research operations. It will focus on the practical concerns faced in industry and highlight those areas not readily available elsewhere. |
|
CHE 530 Introduction to Pharmaceutical ManufacturingClose
Pharmaceutical manufacturing is vital to the success of the technical operations of a pharmaceutical company. This course is approached from the need to balance company economic considerations with the regulatory compliance requirements of safety, effectiveness, identity, strength, quality, and purity of the products manufactured for distribution and sale by the company. Overview of chemical and biotech process technology and equipment, dosage forms and finishing systems, facility engineering, health, safety, & environment concepts, and regulatory issues. |
|
CHE 531 Process Safety ManagementClose
This course reviews the 12 elements of the Process Safety Management (PSM) model created by the Center for Chemical Process Safety of the American Institute of Chemical Engineers. PSM systems were developed as an expectation/demand of the public, customers, in-plant personnel, stockholders and regulatory agencies because reliance on chemical process technologies were not enough to control, reduce and prevent hazardous materials incidents. PSM systems are comprehensive sets of policies, procedures and practices designed to ensure that barriers to major incidents are in place, in use and effective. The objectives of this course are to: define PSM and why it is important, describe each of the 12 elements and their applicability, identify process safety responsibilities, give real examples and practical applications to help better understand each element, share experiences and lessons learned of all participants, and assess the quality and identify enhancements to student's site PSM program. |
|
CHE 535 Good Manufacturing Practice in Pharmaceutical Facilities DesignClose
Current Good Manufacturing Practice compliance issues in design of pharmaceutical and biopharmaceutical facilities. Issues related to process flow, material flow, and people flow, and A&E mechanical, industrial, HVAC, automation, electrical, and computer. Bio-safety levels. Developing effective written procedures, so that proper documentation can be provided, and then documenting through validation that processes with a high degree of assurance do what they are intended to do. Levels I, II, and III policies. Clinical phases I, II, III and their effect on plant design. Defending products against contamination. Building quality into products. |
|
CHE 539 / PME 539 Bioprocess Technology in API ManufacturingClose
This course provides a broad overview of topics related to the design and operations of modern biopharmaceutical facilities. It covers process, utilities and facility design issues, and encompasses all major manufacturing areas, such as fermentation, harvest, primary and final purification, media and buffer preparation, equipment cleaning and sterilization, and critical process utilities. Unit operations include cell culture, centrifugation, conventional and tangential flow filtration, chromatography, solution preparation, and bulk filling. Application of current Good Manufacturing Practices and Bioprocessing Equipment Standards (BPE-2002) will be discussed. |
|
CHE 540 Validation and Regulatory Affairs in Pharmaceutical ManufacturingClose
Validation of a pharmaceutical manufacturing process is an essential requirement with respect to compliance with Good manufacturing Practices (GMP) contained within the Code of Federal Regulations (21 CFR). Course covers validation concepts for plant, process, cleaning, sterilization, filtration, analytical methods, and computer systems; GAMP (Good Automated Manufacturing Practice), IEEE SQAP, and new electronic requirements – 21 CFR Part 11. Master validation plan, IQ, OQ, and PQ protocols, and relationships to GMP. National (FDA) and international (EU) regulatory affairs for cGMP (current Good Manufacturing Practice) and cGLP (current Good Laboratory Practice) requirements in development, manufacturing, and marketing. Handling the FDA inspection. |
|
CHE 541 Validation of Computerized SystemsClose
Computers and computerized systems are ubiquitous in pharmaceutical manufacturing. Validation of these systems is essential to assure public safety and compliance with appropriate regulatory issues regarding validation: GMP, GCP, 21CFR Part 11, etc. This course covers validation concepts for various classes of computerized systems and applications used in the pharmaceutical industry; importance of requirements engineering in validation; test protocols and design; organizational maturity considerations. |
|
CHE 564 Microprocessors in Process ControlClose
Designed to provide the process engineers with the background necessary to understand and work with microprocessor -based systems. Topics include: introduction and overview of microprocessor-based technology in chemical engineering; analog and digital signal conditioning, data transmission and serial interfacing using RS-232C and GPIB IEEE-488standards; analog-to-digital conversion and sampling; digital-to-analog conversion; digital I/O, switches/relays, and power supplies; microprocessor-based sensors, transducers and actuators; programmable logic controllers and batch process control; software packages for data-acquisition and control. |
|
CHE 610 Process Synthesis, Analysis and DesignClose
Development and evaluation of processing schemes; analysis of process circuits; establishing design criteria; process design; evaluation and selection of process equipment: economic analysis and evaluation; applications to chemical, biochemical, waste treatment, energy and other processes of current interest. |
|
CHE 611 Design of Separation ProcessesClose
Selection, design, and scaling of separation processes using principles of momentum, energy, and mass transfer; applications to novel as well as to conventional separation techniques. |
|
CHE 612 Stagewise OperationsClose
The ultimate goal of this course is to prepare students to undertake the analysis of the most difficult problems in equilibrium stage operations. The problems typically, involve one or more columns with components exhibiting highly non-ideal behavior. This class of problems includes azeotropic distillation, extractive distillation, columns with more than one liquid phase, and a variety of other anomalies. Lack of complete equilibrium dat is not uncommon. Extensive use is made of commercialsoftware in the solution of problems. The course concludes with the assignment of an industrial problem, a substantial project, which requires that the students exercise virtually all techniques studied. |
|
CHE 613 Similarity & ScalingClose
Concepts of similarity and dimensional analysis; models, scaling, correlation of physical and engineering properties, applications in chemical engineering design.
|
|
CHE 620 Chemical Engineering ThermodynamicsClose
This course supplements the clasical undergraduate thermodynamics course by focusing on physical and thermodynamic properties, and phase equilibria. A variety of equations of state, and their applicability, are introduced as are all of the important liquid activity coefficient equations. Customization of both vapor and liquid equations is introduced by appropriate methods of applied mathematics. Vapot-liquid, liquid-liquid, vapor-liquid-liquid and solid-liquid equilibria are considered with rigor. Industrial applications are employed. A variety of methods for estimating physical and thermodynamic properties are introduced. Students are encouraged to use commercial software in applications. The course concludes with an introduction to statistical thermodynamics.
|
|
CHE 628 Pharmaceutical Finishing and Packaging SystemsClose
The course covers finished product manufacturing and packaging systems in the pharmaceutical industry, concentrating on the oral solid dosage forms. Process unit operations include blending, granulating, size reduction, drying, compressing, and coating for tablets, as well as blending and filling for capsules. Design and operation of packaging equipment for tablet and capsule counting, capping, security sealing, labeling, cartoning, and case packing will be considered. Approach for development of project documentation, such as equipment specifications, purchase orders, test plans, and validation documents will be presented. Use of computer simulation tools for system development and improvement will be discussed. Term paper project will require students to collectively design a solid dosage manufacturing and packaging facility, considering selection of processing and packaging equipment, material flow, development of commissioning and qualification plan and protocols. |
|
CHE 630 / PME 639 Theory of Transport ProcessesClose
Generalized approach to differential and macroscopic balances: constitutive material equations; momentum and energy transport in laminar and turbulent flow; interphase and intraphase transport; dimensionless correlations |
|
CHE 638 Chemical Technology Processes in API ManufacturingClose
Bulk active pharmaceutical ingredient manufacturing and unit operations.
Process scale-up. Transport processes, including mass, heat, and momentum transfer. Process synthesis, analysis, and design. Traditional separation processes, including distillation, evaporation, extraction, crystallization, and absorption. New separation processes, including pressure swing adsorption, molecular sieves, ion exchange, reverse osmosis, microfiltration, nanofiltration, ultrafiltration, diafiltration, gas permeation, pervaporation, supercritical fluid extraction, and high performance liquid chromatography (HPLC). Batch and continuous reactors for homogeneous, heterogeneous, catalytic, and non-catalytic reactions. |
|
CHE 639 / PME 639 Modeling and Simulation of Pharmaceutical Manufacturing SystemsClose
This course will introduce students to the modeling and simulation applications in the pharmaceutical manufacturing. Learn the basics of discreet event simulation and use commercially available software to develop models of various manufacturing and service systems. Approaches to the development of conceptual and computer models, data collection and analysis, model verification and validation, simulation output analysis are discussed. Learn how to model chemical, biochemical and separation processes in pharmaceutical manufacturing using process simulation software. Develop material balances, stream reports, operations and equipment Gantt charts, conduct process debottlenecking and cost analysis. |
|
CHE 641 New Separation ProcessesClose
The course begins with a review of traditional separation processes such as distillation, evaporation, extraction, crystallization and absorption. New topics in separation which are covered include pressure swing adsorption, molecular sieves, ion exchange, reverse osmosis, microfiltration, nano-filtration, ultrafiltration, diafiltration, gas permeation, pervaporation, supercritical fluid extraction, and liquid chromatography. Industrial applications, design considerations, and engineering analysis of these separation topics are covered. |
|
CHE 646 Biopharmaceuticals Facilities DesignClose
Proven techniques and creative tools presented for design, development, and delivery of biopharmaceutical manufacturing facilities. Includes skills and knowledge in bioprocessing requirements, equipment and facility requirements, project management as well as regulatory guidelines and big-picture drug development. Also corporate capital management processes to functionally meet corporate requirements from pre-clinical to commercial scale of operations, qualifications to pass regulatory inspections, achieving faster time-to-market, but not breaking the corporate treasury bank. Course also explores trends in new equipment technology such as disposables or single-use product, new design concepts in aseptic manufacturing, barrier and isolation technologies, new FDA thinking in risk-based compliance approach, process analytical technology, capital project planning and management. |
|
CHE 649 Design of Water, Steam, and CIP Utility Systems for Pharmaceutical ManufacturingClose
Water & steam systems: (water used as excipient, cleaning agent, or product diluent) water quality selection criteria; generation, storage and
distribution systems; bio-burden control; USP PWS (purified water systems) and USP WFI (water for injection) systems; engineering considerations, including specification, design, installation, validation, operation, testing, and maintenance; common unit operations, including deionization, reverse osmosis, distillation, ultrafiltration, and ozonation systems; process considerations, including pretreatment, storage and distribution, materials of construction, microbial control, pyrogen control, and system maintenance; FDA requirements; clean-in-place systems; steam generation and distribution systems. |
|
CHE 650 Reactor DesignClose
Analysis of batch and continuous chemical reactions for homogeneous, heterogeneous, catalytic, and non-catalytic reactions; influence of temperature, pressure, reactor size and type, mass and heat transport on yield and product distribution; design criteria based on optimal operating conditions and reactor stability will be developed. |
|
CHE 652 Environmental CatalysisClose
This course describes the application of catalysis to modern air pollution
control. A practical description of catalysts and their fundamental
properties provides a foundation for understanding modern catalytic converters used for reducing hydrocarbon, carbon monoxide, and nitric oxide emissions from gasoline and diesel fueled vehicles, power plants, chemical facilities, etc. It is intended for graduate students in any engineering or science discipline interested in environmental control technology. |
|
| CHE 653 Design of PAT Systems for Pharmaceutical ManufacturingClose
The objective of this course is to provide the student with the engineering tools and knowledge required to design and deploy Process Analytical Technology (PAT) solutions in pharmaceutical drug substance and drug product manufacturing. This course provides in-depth coverage of current PAT technologies. At the conclusion of this course, students will understand the engineering theory, principles, and mathematics required to design and deploy these technologies in a pharmaceutical manufacturing environment in compliance with FDA and international regulations. Topics covered include: analyzer types and principals of operation, chemometric techniques for multivariate analysis, multivariate process models, dynamic process control, and advanced pattern recognition techniques. In addition, the course will cover the technical aspects of real-time data management and 21 CFR Part 11 compliance. |
|
CHE 660 Advanced Process ControlClose
Mathematical modeling and identification of chemical processes. State-space process representation and analysis: stability, observability, controllability and reach-ability. Analysis and design of advanced control systems: internal model control, dynamic matrix control and model predictive control. Synthesis of multivariable control systems: interaction analysis, singular value decomposition, decoupler design. Continuous and sampled-data systems, on-line process identification. State and parameter estimation techniques: Luenberger observer and Kalman filter. Knowledge of Laplace transforms, material and energy balances, computer programming and matrix algebra is required. |
|
CHE 662 Chemical Process SimulationClose
The course comprises a series of workshops, employing an industrial process simulator, Aspen Plus, which explore the primary components required to simulate a chemical process. Most workshops have embedded irregularities designed to heighten the student awareness of the types of errors that could arise when using simulation software. The workshops include facilities to exercise and customize a wide variety of physical and thermodynamic properties as the students develop process models. Heavy concentration is on the equations describing the models used. As the experience level of the students rises, workshops designed to introduce complicated industrial flowsheets are employed. |
|
CHE 670 / MT 670 Polymer Properties and StructureClose
Stress-strain relationships, theory of linear viscoelasticity and relaxation spectra, temperature dependence of viscoelastic behavior, dielectric properties, dynamic mechanical and electrical testing, molecular theories of flexible chains, statistical mechanics and thermodynamics of rubber-like undiluted systems, morphology of high polymers. |
|
CHE 671 Polymer RheologyClose
Molecular and continuum mechanical constitutive equations for viscoelastic fluids; analysis of viscometric experiments to evaluate the viscosity and normal stress functions: dependence of these functions on the macromolecular structure of polymer melts: solution of isothermal and nonisothermal flow problems with non-Newtonian fluids which are encountered in polymer processing; development of design equations for extruder dies and molds. |
|
CHE 672 Processing of Polymers for Biomedical ApplicationsClose
Descriptions of various polymer processing operations and processing requirements of biomedical products, principles of processing of polymers covering melting, pressurization, mixing, devolatilization, shaping using extrusion, spinning, blowing, coating, calendering and molding technologies, surface treatment and sterilization, applications in the areas of prostheses and artificial organs and packaging of various biomedical devices. |
|
CHE 673 Polymerization EngineeringClose
Analysis and design of experimental and industrial polymerization reactors for various polymerization mechanisms: relationship between design parameters and polymer structure, yield and average molecular weight: kinetic and statistical methods; batch and continuous, addition and condensation polymerization in bulk, solution, suspension and emulsion.
|
|
CHE 674 Design of Polymer Processing MachineryClose
A treatment of polymer processing machinery with emphasis on the design of components to implement the various elementary steps involved, and subsequent assembly of these components into processing machines. Use is made of computational models. Principles of control systems are applied to processing machinery. The primary objective is to stimulate creative approaches to the design of processing machinery rather than to familiarize the student with the details of existing machinery.
|
|
CHE 675 Polymer Blends and CompositesClose
Recent advances in polymer blend and composite formation; the role of melt rheology in component selection and the resulting morphology; melt mixing processes and equipment; models for predicting processing and performance characteristics; morphology generation and control in manufacturing processes; sample calculations and case histories for polyblends used in film blowing, blow molding and injection molding. |
|
CHE 676 Polymer Mold and Die DesignClose
Principal manufacturing methods utilizing molds and dies; mold and die design characteristics dictated by functional requirements; interaction between molds/dies and processing machinery; mathematical models of forming processes including: flow through dies and into molds, solidification, heat transfer and reaction (in reactive processing); end-product properties (morphology, bulk properties, tolerances, appearance) and operating conditions in alternative manufacturing methods; materials and manufacturing methods for molds and dies; case studies. |
|
CHE 677 Polymer Product DesignClose
Design of polymeric products; design criteria based upon product functions and geometry; material selection by property assessment; selection of molds, dies, and special manufacturing devices (e.g., mold inserts); selection of appropriate forming process (injection, rotational or blow-molding, extrusion, etc.), and determination of optimum operating conditions (such as temperature, pressure, cycle or residence time). Case histories of failure. |
|
CHE 678 Experimental Methods in Polymer Melt RheologyClose
Discussion of models for flow and deformation in polymers, and a treatment of measurable rheological properties. Analysis of thermoplastic and thermosetting resins for processability. Use of experimental data to determine parameters of the constitutive equations. Laboratory includes use of state-of-art equipment in elongational, rotational, and capillary viscometry. |
|
CHE 682 Colloids and Interfacial PhenomenaClose
A survey course covering the chemical, biological and material science aspects of interfacial phenomena. Applications to adhesion, biomembranes, colloidal stability, detergency, lubrication, coating, fibers, and powders - were surface properties play an important role. Prerequisites: Physical Chemistry and Thermodynamics. |
|
CHE 695 / BME 695 Bio/Nano PhotonicsClose
This course deals with the principles of light interactions with biological and biomedical-relevant systems. The enabling aspects of nanotechnology for advanced biosensing, medical diagnosis, and therapeutically treatment will be discussed. |
|
CHE 703 Numerical Methods in Chemical EngineeringClose
The course is designed to enable students to attack a variety of chemical engineering problems which lend themselves to solution by numerical methods as opposed to classical mathematics. Problems that do not fir the mold "use existing software" are illustrated. The students are encouraged to create their own software to solveproblems. For this purpose students are given an introduction to the Visual Basic programming language. Students are also encouraged to use more advanced methods in Excel. Examples and homework assignments are drawn from industrial experience when possible. |
|
|
Print