Perlman Lab

Perlman Lab

Our laboratory studies lung mechanics in the context of acute lung injury. One hallmark of acute lung injury is pulmonary edema, where liquid leaks out of the blood vessels into the airspace of the lung. This liquid-filling of the airspace causes patients to have difficulty breathing. Thus to support gas exchange, patients with acute lung injury are treated with mechanical ventilation. To provide sufficient gas exchange, however, mechanical ventilation can cause over-distension injury of the lungs and prevent recovery.  The mortality rate is about 30% and patients often die from the ventilator injury, not the underlying lung disease.

To address this problem, we study the inflation mechanics of the edematous lung. Our goal is to use our understanding of mechanics to inform development of novel treatment methods that reduce ventilator induced lung injury.