Biological principles and their physical and chemical aspects are explored at the cellular and molecular level. Major emphasis is placed on cell structure, the processes of energy conversion by plant and animal cells, genetics and evolution, and applications to biotechnology.
Research & Education
Education
Georgetown University, B.S Biology 1987
University of TexasSouthwestern Medical Center, Ph.D. Neuroscience, 1993
Columbia University College ofPhysicians and Surgeons, Aaron Diamond Post-Doctoral Fellow, 1993-1996
Professor and Director, Department of Chemistry, Chemical Biology, & Biomedical Engineering, 2008 - present
Experience
Weill Cornell Medical College, New York, NY
Assistant Professor of Biochemistry in Medicine, 1996-2004
Assistant Professor of Genetic Medicine, 2000-2004
Associate Professor of Genetic Medicine, 2004-2008
Associate Professor of Biochemistry in Medicine, 2004-2008
Technogenesis Service
Mentor, Shyam Shah, Technogenesis Scholar, 2009
Achievements & Professional Societies
Honors & Awards
Georgetown University Biology Medal, 1987
Weill Medical College Excellence in Teaching Award, 2002
Weill Medical College Charles L. Bardes Teaching Prize, 2005
Patents & Inventions
Crystal RG, Sato N, Leopold PL.Method of modulating hair growth. United States Patent #6,159,950.
Professional Societies
New York Society of Experimental Microscopists, President, 2001-2003
Harvey Society, 2003-present
American Society for Gene Therapy, Education Committee Chair, 2006-2008
Selected Publications
Journals
Leopold PL,* O’Mahony MJ,* Lian XJ,* Harvey BG, Crystal RG. "Smoking is associated with shortened airway cilia ", PLoS ONE, (in press) [* - these authors contributed equally to the work].
Vincent T, Neve EPA, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.. (2009). "A Snail-Smad transcriptional repressor complex promotes TGF-β-mediated epithelial-mesenchymal transition ", Nature Cell Biology, 11 943-950.
Berth SB, Leopold PL, Morfini G.. (2009). "Virus-induced neuronal dysfunction and degeneration. ", Frontiers in Bioscience, 14 5239-5259.
Kiuru M, Hidaka C, Hubner R-H, Krause A, Leopold PL, Crystal RG.. (2009). "Transient systemic overexpression of Sonic hedgehog mediates expansion of diaphyseal trabecular bone with associated amplification of the hematopoietic stem cell niche.", Molecular Therapy, 17 1442-1452.
Hubner R-H, Kiuru M, Krause A, Leopold PL, Crystal RG.. (2009). "Dysfunction in glycogen storage with metabolic consequences in a mouse model of Alpha 1-Antitrypsin Deficiency", Am. J. Resp. Cell Molec. Biol., 40 239-247.
Saitoh H, Leopold PL, Harvey B-G, O'Connor TP, Worgall S, Hackett NR, Crystal RG. (2009). "Emphysema Mediated by Lung Overexpression of ADAM10", Clin Transl Sci, 2 50-56.
Song Y, Lou HH, Boyer JL, Limberis MP, Vandenberghe LH, Hackett NR, Leopold PL, Wilson JM, Crystal RG. (2009). "Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing", Hum Gene Ther, 20 267-281.
Leopold PL, Crystal RG. (2007). "Intracellular trafficking of adenovirus: Many means to many ends", Advanced Drug Delivery Reviews, 59 810-821.
Leopold PL, Wendland R, Vincent T, Crystal RG. (2006). "Neutralized adenovirus-immune complexes can mediate effective gene transfer via a Fc receptor-dependent infection pathway", Journal of Virology, 80 10237-10247.
Leopold PL, Pfister KK. (2006). "Viral strategies for intracellular trafficking: motors and microtubules", Traffic, 7 516-523.
Kelkar S, De B, Gao G, Wilson JM, Crystal RG, Leopold PL. (2006). "A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes", Journal of Virology, 80 7781-7785.
Lou H, Crystal RG, Leopold PL. (2005). "Enhanced in vivo efficacy of cholesterol-minus Sonic hedgehog", Molecular Therapy, 12 575-578.
Conference Proceedings
Leopold PL. (2007). "Viruses as Mentors for Nano-scale Drug Delivery", Eighth Annual Nanobiotechnology Symposium. Cornell University Nanobiotechnology Center.
Book Chapters
Leopold PL. (2007). "Chapter 34: Microtubule-dependent motility during intracellular trafficking of vector genome to the nucleus: Subcellular mimicry in virology and nanoengineering", Nanotechnology in Biology and Medicine, T. Vo-Dinh, Taylor and Francis, Inc./CRC Press Inc., London.
The mission of the Department of Chemistry, Chemical Biology, and Biomedical Engineering is to exploit the natural interdependence of science and engineering...read more
