faculty-profile

Yong Zhang

ASSOCIATE PROFESSOR, CHEMISTRY
Building: McLean Hall
Room: 114
Phone: 201-216-5513
Fax: 201-216-8240
Email: yzhang37@stevens.edu
Department:  Chemistry, Chemical Biology & Biomedical Engineering
Program:  Chemistry & Chemical Biology / Chemistry
Education

1997 Ph.D. Chemistry, Nanjing University

1993 B.S. Chemistry, Nanjing University


2007-2010 Assistant Professor Chemistry, University of Southern Mississippi

2000- 2007 Research Scientist, University of Illinois Urbana-Champaign (with Eric Oldfield)

1999-2000 Associate Professor of Chemistry (Tenured), Nanjing University
Research

High-Accuracy Computational Chemistry

  • Molecular design and mechanisms of metal-centered pharmaceuticals to combat cancer and neurodegenerative diseases
  • Structural and functional investigation of novel metallobiomolecules involved in cellular regulation and signaling 
  • Molecular toxicities of environmentally hazardous compounds and design of protective and detoxifying agents
  • Structural and functional fingerprints of interesting molecules and biomolecules

Postdoctoral Research Position Available

 

                      

                 Meet my Research Group

Professional Societies
American Chemical Society, 2003-present
American Association for the Advancement of Science, 2007-present
Mississippi Academy of Sciences, 2009-present
Society of Porphyrins and Phthalocyanines, 2009-present
Society of Biological Inorganic Chemistry, 2009-present
Chinese Chemical Society, 1999-2000
Selected Publications
Journals
  1. Selected Publications..... .  ( See Complete List )  .
  2. Li JK, Wang K, Smirnova, Khade RL, Zhang Y, Oldfield E.. (2013). "Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis", Angew. Chem. Int. Ed, 52 6522-25.
  3. Liu YL, Guerra F, Wang K, Huang CC, Wang WX, Zhu W, Houlihan K, Li Z, Demeler B, Zhang Y, Nair S, Oldfield E.. (May 29, 2012). "Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins", Proc. Natl. Acad. Sci. U. S. A., 109 (22), 8558-8563.
  4. Yang L, Ling Y, Zhang Y. (2011). "HNO Binding in a Heme Protein: Structures, Spectroscopic Properties, and Stabilities", J. Am. Chem. Soc., 35 (133), 13814-13817.
  5. Wang WX, Li JK, Wang K, Huang CC, Zhang Y, Oldfield E.. (2010). "Organometallic Mechanism of Action and Inhibition of the 4Fe-4S Isoprenoid Biosynthesis Protein GcpE", Proc. Natl. Acad. Sci. U. S. A., 107 (25), 11189-93.
  6. Wang K, Wang WX, No JH, Zhang YH, Zhang Y, Oldfield E. (2010). "Inhibition of the Fe4S4 Cluster-containing Protein IspH (LytB): EPR, Metallacycles and Mechanisms.", J. Am. Chem. Soc, 132 (19), 6719-6727 .
  7. Ling Y, Mills C, Weber R, Yang L, Zhang Y. (2010). "NMR, IR/Raman, and Structural Properties in HNO and RNO (R = alkyl and aryl) Metalloporphyrins with Implications for the HNO-myoglobin Complex", J. Am. Chem. Soc., 132 (5), 1583-91.
  8. Stevenson S, Ling Y, Coumbe CE, Mackey MA, Confait BS, Phillips JP, Dorn HC, Zhang Y. (2009). J. Am. Chem. Soc., 131 (49), 17780-82.
  9. Ling Y, Zhang Y. (2009). "Mössbauer, NMR, Geometric, and Electronic Properties in S = 3/2 Iron Porphyrins", J. Am. Chem. Soc., 131 (18), 6386-8.
  10. Zhang Y, Oldfield E.. (2008). "NMR Hyperfine Shifts in Blue Copper Proteins: a Quantum Chemical Investigation", J. Am. Chem. Soc., 130 (12), 3814-23.
  11. Mukkamala D, Zhang Y, Oldfield E.. (2007). "A Solid State 13C NMR, Crystallographic and Quantum Chemical Investigation of Phenylalanine and Tyrosine Residues in Dipeptides and Proteins", J. Am. Chem. Soc., 129 (23), 7385-92.
  12. Kervern G, Pintacuda G, Zhang Y, Oldfield E, Roukoss C, Kuhn E, Herdtweck E, Basset JM, Cadars S, Lesage A, Coperet C, Emsley L.. (2006). "Solid-state NMR of a paramagnetic DIAD-Fe(II) catalyst: sensitivity, resolution enhancement, and structure-based assignment", J. Am. Chem. Soc., 128 (41), 13545-52.
  13. Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, Song YC, Zhang YH, Meints GA, Gao YG, Mukkamala D, Hudock MP, Oldfield E.. "A Solid State NMR, Crystallographic and Computational Investigation of Bisphosphonates and Farnesyl Diphosphate Synthase-Bisphosphonate Complexes", J. Am. Chem. Soc., 128 (45), 14485-97.
  14. Zhang Y, Sun H, Oldfield E.. "Solid-state NMR Fermi Contact and Dipolar Shifts in Organometallic Complexes and Metalloporphyrins", J. Am. Chem. Soc., 127 (11), 3652-3.
  15. Zhang Y, Mukherjee S, Oldfield E. (2005). "67Zn NMR Chemical Shifts and Electric Field Gradients in Zinc Complexes: A Quantum Chemical Investigation", J. Am. Chem. Soc., 127 (8), 2370-1.
  16. Cheng F, Sun H, Zhang Y, Mukkamala D, Oldfield E.. (2005). "A Solid State 13C NMR, Crystallographic and Quantum Chemical Investigation of Chemical Shifts and Hydrogen Bonding in Histidine Dipeptides", J. Am. Chem. Soc., 127 (36), 12544-54.
  17. Zhang Y, Oldfield E.. (2004). "Cytochrome P450: An Investigation of the M÷ssbauer Spectra of a Reaction Intermediate and a Fe(IV)=O Model System", J. Am. Chem. Soc., 126 (14), 4470-1.
  18. Zhang Y, Oldfield E.. (2004). "On the Mössbauer Spectra of Isopenicillin N Synthase and a Model {FeNO}7 (S=3/2) System", J. Am. Chem. Soc., 126 (31), 9494-5.
  19. Zhang Y, Gossman W, Oldfield E.. (2003). "A Density Functional Theory Investigation of Fe-N-O Bonding in Heme Proteins and Model Systems", J. Am. Chem. Soc., 125 (52), 16387-96.
  20. Zhang Y, Mao J, Oldfield E. (2002). "57Fe Mössbauer Isomer Shifts of Heme Protein Model Systems: Electronic Structure Calculations", J. Am. Chem. Soc., 124 (26), 7829-39.
  21. Zhang Y, Mao J, Godbout N, Oldfield E.. (2002). "Mössbauer Quadrupole Splittings and Electronic Structure in Heme Proteins and Model Systems: A Density Functional Theory Investigation", J. Am. Chem. Soc., 124 (46), 13921-30.
  22. Mao J, Zhang Y, Oldfield E.. (2002). "Nuclear Magnetic Resonance Hyperfine Shifts in Paramagnetic Metalloporphyrins and Metalloproteins", J. Am. Chem. Soc., 124 (46), 13911-20.
  23. Zhang Y, Guo ZJ, You XZ. (2001). "Hydrolysis Theory for Cisplatin and Its Analogues Based on Density Functional Studies", J. Am. Chem. Soc., 123 (38), 9378-87.
Courses
  • CH 322 Theoretical Chemistry
  • CH 421 Chemical Dynamics
  • CH 520 Advanced Physical Chemistry
  • H 186 Research Seminar IV