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| Athula B. Attygalle | |  |
 | | Athula B. Attygalle | | Research Professor, Chemistry | | Location: | 312 McLean Chemical Sciences Building |
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CH 362:Instrumental Analysis I - Spectroscopy and Chromatography
Theoretical and experimental approach to spectroscopy and chromatography. Includes ultraviolet, visible and infrared absorption by molecules, emission spectroscopy, nuclear magnetic resonance, mass spectroscopy and gas-liquid and high-performance chromatography. |
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CH 461:Instrumental Analysis II - Electrochemistry
Theory and practice of electrochemical methods in analytical chemistry. Includes potentiometry, coulometry, amperometry, polarography, voltammetry, conductivity, etc.
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CH 662:Separation Methods in Analytical and Organic Chemistry
An advanced course applying principles and theory to problems in chemical analysis. Theory of separations, including distillation, chromatography, and ultracentrifugation; heterogeneity and surface effects; and sampling and its problems. |
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CH 666:Modern Mass Spectrometry
A comprehensive hands-on course covering both fundamentals and modern aspects of mass spectrometry, with emphasis on biological and biochemical applications. Topics include: contemporary methods of gas phase ion formation [electron ionization (EI), chemical ionization (CI), inductively coupled plasma (ICP), fast atom bombardment (FAB), plasma desorption (PD), electrospray (ESI), atmospheric pressure chemical ionization (APCI), matrix assisted laser desorption ionization (MALDI), detection (electron and photomultipliers, and array detectors), and mass analysis [magnetic deflection, quadrupole, ion trap, time of flight (TOF), and Fourier-transform (FTMS)]. Detailed interpretation of organic mass spectra for structural information, with special emphasis on even-electron-ion fragmentation. Qualitative and quantitative applications in environmental, biological, pharmacological, forensic, and geochemical sciences. |
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| | School: Schaefer School of Engineering & Science | | Department: Chemistry, Chemical Biology & Biomedical Engineering | Program: Chemistry & Chemical Biology
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| | Research & Education | |
| | | | Research | - Mass Spectrometrric Ion fragmentations
- Bioanalytical Chemistry
- Microchemical techniques
- Chromatography
- GC-Infrared Spectrometry
- Natural Products
- Chemical Communication and Defense in Arthropods
- Chemical Ecology
- “Chemical Prospecting” by Pharmacological Screening of Tropical Rain Forest Natural Products.
| | Education | | - B.Sc. (Chemistry), University of Ceylon, 1975
- M.Sc. (Biochemistry)University of Sri Lanka, 1977
- Postgraduate Diploma in Chemistry and Chemical Engineering, Tokyo Institute of Technology, Tokyo, Japan, , 1979
- Ph. D. (Chemistry) University of Keele, United Kingdom, 1983
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| | Achievements & Professional Societies | |
| | Patents & Inventions | - Insect Deterrent Azamacrolides, Eisner, T., Attygalle, A.B., and McCormick, K.D. U.S. Patent No. 5,185,365.
- Tetradecatrienyl and tetradecadienyl acetates and their use as sex attractants for tomato pests., Attygalle, A. B., Jham, J. N., Svatos, A., Frighetto, R. T. S. U.S. Patent No. 5,728,376.
- Macrocyclic Polyamine Lactones & Derivatives Thereof & Their Use as Arthropod Repellents. Attygalle, A. B., Eisner, T., Farmer J., Meinwald J., Schroeder F., Smedley S. U.S. Patent No. 6,384,026
- Analyte Ionization by Charge Exchange for Sample Analysis under Ambient Conditions. Chang-Chin Chan, Mark Bolgar, Scott Miller, Zhihua Yang, Athula B. Attygalle. U.S. Patent App # 12/893597.
- Combined Liquid/Gas (LIGA) inlet for Sample Analysis by liquidchromatography and gas chromatography-mass spectrometry under ambient conditions. Athula Attygalle, Zhihua Yang. U.S. Patent App # 61/319502.
- Analyte ionization by charge exchange for sample analysis under ambient conditions. Chang-Ching Chan, Mark Bolgar, Scott Miller, Zhihua Yang, Athula B. Attygalle. U.S. Patent App # 61/381352.
- A Production Method for Gas Phase Metal anions. Athula B. Attygalle, Carl Weisbecker. U.S. Patent App # 61/317079.
| | Honors & Awards | - 1979, UNESCO Fellowship (Tokyo Institute of Technology)
- 1981, British Council Award for Graduate Tuition Fee Support
- 1982, Edwina Mountbatten Award
- 1984, Alexander von Humboldt Foundation Fellowship, Germany
| | Grants, Contracts & Funds | | COLLABORATIVE RESEARCH: CHEMICAL ECOLOGY OF HOST SPECIALIZATION IN PHORID PARASITOIDS OF ANT: AN EXPERIMENTAL ANALYSIS. National Science Foundation Award # 1052372 (Sept 2011- Agust 2014) |
| | | Professional Societies | | - Member of the American Chemical Society
- Member of the American Society for Mass Spectrometry
- Member of the Editorial Advisory Board, "Mini Reviews in Organic Chemistry" 2003-current.
- Executive Editor "Current Organic Chemistry" 2002-current.
- Member of the Editorial Advisory Board of “The Open Physical Chemistry Journal” 2009-
- Member of the Editorial Advisory Board of “The Open Spectroscopy Journal.” 2009-
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| | Selected Publications | |
| Journals
Andrew Kruegel, Julius Pavlov and Athula B. Attygalle*. (Feb 18, 2013). "Enhancement of laser desorption ionization mass spectrometric", Rapid Commununications in Mass Spectrometry, John Wiley. 27 763-766.
Julius Pavlov and Athula B. Attygalle. (Jan 1, 2013). "Direct Detection of Inorganic Nitrate Salts by Ambient Pressure Helium-Plasma Ionization Mass Spectrometry", Analytical Chemistry , American Chemical Society. 85 (1), 278-282.
Freneil B. Jariwala, Ryan E. Wood, Upul Nishshanka, and Athula B. Attygalle. (2012). "Formation of the Bisulfite Anion (HSO3–, m/z 81) upon Collision-Induced Dissociation of Anions Derived from Organic Sulfonic Acids", Journal of Mass S[pectrometry, John Wiley. 47 529–538.
Zhihua Yang, Julius Pavlov and Athula B. Attygalle. (2012). "Quantification and remote detection of nitro explosives by helium plasma ionization mass spectrometry (HePI-MS) on a modified atmospheric pressure source designed for electrospray ionization ", Journal of Mass. Spectrometry, Wiley. 47 845-852.
Jose Castro-Perez, Thomas P. Roddy, Nico M.M. Nibbering, Vinit Shah, David G. McLaren, Stephen Previs, Athula B. Attygalle, Kithsiri Herath, Zhu Chen, Sheng-Ping Wang, Lyndon Mitnaul1, Brian K. Hubbard, Rob J. Vreeken,, Douglas G. Johns, Thomas Hankemei. (2011). "Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry", J. Am. Soc. Mass Spectrom, 22 1515-1525. 1552 – 1567.
Athula B. Attygalle, Upul Nishshanka, and Carl S. Weisbecker. (2011). "Meta Effect” in Mass Spectrometric fragmentation of Gaseous Ions", J. Am. Soc. Mass Spectrom, 22 1515-1525.
Zhihua Yang and Athula B. Attygalle. (2011). "Aliphatic Hydrocarbon Spectra by Helium Ionization Mass Spectrometry (HIMS) on a Modified Atmospheric–Pressure Source Designed for Electrospray Ionization", J. Am. Soc. Mass Spectrom, 22 1395-1402.
LASER IONIZATION MASS SPECTROMETRY OF INORGANIC IONS. (2011). "Julius Pavlov and Athula B. Attygalle in “Applied Mass Spectrometry Handbook”", Mike Lee, John Wiley & Sons.
Athula B. Attygalle, Frank U. Axe, and Carl S. Weisbecker. (2011). "Mild Route to Generate Gaseous Metal Anions", Rapid Commun. Mass Spectrom, 25 681-688.
Josef Ruzicka, Carl Weisbecker, and Athula B. Attygalle. (2011). "Collision-Induced Dissociation Mass Spectra of Positive Ions Derived from Tetrahydropyranyl (THP) Ethers of Primary Alcohols", J. Mass Spectrom, 46 12–23.
Chang-Ching Chan, Mark S. Bolgar, Scott A. Miller, and Athula B. Attygalle. (2011). "A Combined Desorption-Ionization by Charge Exchange (DICE) and Desorption-Electrospray Ionization (DESI) Source for Mass Spectrometry.", J. Am. Soc. Mass Spectrom, 22 173-178.
Chang-Ching Chan, Mark S. Bolgar, Scott A. Miller, and Athula B. Attygalle. (Feb 1, 2011). "A Combined Desorption-Ionization by Charge Exchange (DICE) and Desorption-Electrospray Ionization (DESI) Source for Mass Spectrometry", Journal of the American Society for Mass Spectrometry, Springer. 22 (2), 173-178.
Athula B. Attygalle, Frank U. Axe, and Carl S. Weisbecker. (Feb 1, 2011). "Mild Route to Generate Gaseous Metal Anions", Rapid Communications in Mass Spectrom.etry 25 (2011) 681-688., John Wiley & Sons. 25 681-688.
Chang-Ching Chan, Mark S. Bolgar, Scott A. Miller, and Athula B. Attygalle. (Jan 1, 2010). "Desorption Ionization by Charge Exchange (DICE) for Sample Analysis under Ambient Conditions by Mass Spectrometry", Journal of the American Soiciety for Mass Spectrometry, 21 1554 –1560.
Chang-Ching Chan, Frank U. Axe, Mark Bolgar and Athula B. Attygalle. (Jan 1, 2010). "Reactivity of gaseous sodiated ions derived from benzene dicarboxylate salts toward residual water in the collision gas", Journal of Mass Spectrometry , John Wiley. 45 1130-1138.
Josef Ruzicka, Carl Weisbecker, and Athula B. Attygalle. (Jan 1, 2011). "Collision-Induced Dissociation Mass Spectra of Positive Ions Derived from Tetrahydropyranyl (THP) Ethers of Primary Alcohols", Journal of Mass Spectrometry , John Wiley. 46 (1), 12-23.
Chan, Chang-Ching, Bolgar, Mark; Miller, Scott; Attygalle, Athula. (Sep 1, 2010). "Evading Metal Adduct Formation during Desorption Ionization Mass Spectrometry", Rapid Communication in Mass Spectrometry, Wiley. 24 2838-2842.
Kipling W. Will, Aman S. Gill, Hyeunjoo Lee and Athula B. Attygalle. (Jan 1, 2010). "Quantification and evidence for mechanically metered release of pygidial secretions in formic acid-producing carabid beetles", Journal of Insect Science, 10 1-17.
Jason B. Bialecki, Josef Ruzicka, Carl S. Weisbecker, M. Haribal, Athula B. Attygalle. (Mar 1, 2010). "Collision-induced dissociationmass spectra of glucosinolate anions", Journal of Mass Spectrometry 2010, 45, 272–283, John Wiley & Sons, Ltd.. 45 (3), 272-283.
Andrew Kruegel and Athula B. Attygalle. (Jan 1, 2010). "Elemental Sulfur as a Versatile Low-Mass-Range Calibration Standard for Laser Desorption Ionization Mass Spectrometry", Journal of the American Society for Mass Spectrometry, Elservier. 12 (1), 112-116.
Athula B. Attygalle, Chang-Ching Chan, Frank U. Axe, and Mark Bolgar. (Jan 1, 2010). "Generation of Gas-Phase Sodiated Arenes such as [(Na3(C6H4)+] from benzene dicarboxylate salts", Journal of Mass Spectrometry, John Wiley & Sons, Ltd. 45 (1), 72-81.
Athula B. Attygalle, Xiaogang Wu, David R. Maddison,, Kipling W. Wil. (Dec 1, 2009). "Lemon-scented beetles: Opposite enantiomers of limonene as major constituents in the defensive secretion of related carabids", Springer. 96 (12), 1443-1449. PDF .
Julius Pavlov, Washington Braida, Adebayo Ogundipe, Gregory O’Connor and Athula B. Attygalle. (Oct 2009). "Generation and Detection of Gaseous W12O41 and Other Tungstate Anions by Laser Desorption Ionization Mass Spectrometry", Journal of the American Society for Mass Spectrometry, 20 (10), 1782-1789.
recent publications..... Complete List .
Jason B. Bialecki, Frank U. Axe, and Athula B. Attygalle. (2009). "Hydroxycarbonyl anion (m/z 45), a diagnostic marker for α-hydroxy carboxylic acids. Journal of Mass Spectrometry.", Journal of Mass Spectrometry 44 (2009) 252-259.
Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh. (2008). "Biosynthetic Studies of Platencin. Tetrahedron Letters", Tetrahedron Letters 49 (2008) 5755–5758, 49 5755.
Freneil B. Jariwala, Margaret Figus, and Athula B. Attygalle. (2008). "Ortho Effect in Electron Ionization Mass Spectrometry of N-Acylanilines Bearing a Proximal Halo Substituent. Journal of American Society for Mass Spectrometry.", Journal of American Society for Mass Spectrometry, 19 1114.
Upul Nishshanka and Athula B. Attygalle. (2008). "Low-energy collision-induced fragmentation of negative ions derived from diesters of aliphatic dicarboxylic acids made with hydroxybenzoic acids. Journal of Mass Spectrometry ", Journal of Mass Spectrometry. 43 (2008) 1502-1511, 42 1512.
Athula B. Attygalle, Jason B. Bialecki, Upul Nishshanka, Carl S. Weisbecker, and Josef Ruzicka. (2008). "Loss of benzene to generate an enolate anion by a site-specific double-hydrogen transfer during CID fragmentation of O-alkyl ethers of ortho-hydroxybenzoic acids. Journal of Mass Spectrometry. ", Journal of Mass Spectrometry 43 (2008) 1224-1234., 43.
Kithsiri B. Herath,, Athula B. Attygalle, Sheo B. Singh. (2007). "Biosynthetic Studies of Platensimycin. Journal of the American Chemical Society.", Journal of the American Chemical Society 129 (2007) 15422-15423., The American Chemical Society . 129 15422.
Siliu Tan, Melek Erol, Athula Attygalle, Henry Du , and Svetlana Sukhishvili. "Synthesis of Positively Charged Silver Nanoparticles via Oxidative Photoreduction of AgNO3 and Branched Polyethyleneimine in HEPES Solutions", Langmuir 23 (2007) 9836-9843.
Hyeunjoo Lee, Steven Finckbeiner, Jose S. Yu, David F. Wiemer, Thomas Eisner, Athula B. Attygalle. (2007). "Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor nutria) by GC-MS and GC-IR. Journal of Chromatography", Journal of Chromatography A 1165 (2007) 136-143 (doi:10.1016/j.chroma.2007.06.041), 1165 136.
Jason B. Bialecki, Josef Ruzicka, and Athula B. Attygalle. (2007). "Synthesis of [2,3,4,5,6-2H5]phenyl glucosinolate. Journal of Labelled Compounds and Radiopharmaceuticals.", Journal of Labelled Compounds and Radiopharmaceuticals. 50 (2007) 711–715.
Athula B. Attygalle, Josef Ruzicka, Deepu Varughese, Jason Bialecki and Sayed Jafri. (2007). "Low-energy collision-induced fragmentation of negative ions derived from ortho-, meta-, and para-hydroxyphenyl carbaldehydes, ketones, and related compounds. Journal of Mass Spectrometry.", Journal of Mass Spectrometry. 42 (2007) 1207–1217, 42.
Václav Čeřovský, Jan Pohl, Zhihua Yang, Naseer Alam, and Athula B. Attygalle. (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major. Journal of Peptide Scence.", Journal of Peptide Scence. 13 (2007) 445 - 450, 13 445.
Xiaogang Wu , Donald W. Buden and Athula B. Attygalle. "Hydroquinones from defensive secretion of a giant Pacific millipede, Acladocricus setigerus (Diplopoda: Spirobolida)", Chemoecology 17 (2007) 131-138. (DOI 10.1007/s00049-007-0372-1).
Athula B. Attygalle, Xiaogang Wu and Kipling W. Will. (2007). "Biosynthesis of tiglic, ethacrylic and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus (Carabidae). Journal of Chemical Ecology ", Journal of Chemical Ecology 33 (2007) 1573-1561 (DOI: 10.1007/s10886-007-9276-3).
Merih Sengonul, J. Ruzicka, A. B. Attygalle, Matthew Libera.. "Surface modification of protein nanocontainers and their self-directing character in polymer blends", Polymer 48 (2007) 3632-3640.
Zhihua Yang and Athula B. Attygalle. (2007). "LC/MS Characterization of Undesired Products Formed During Iodoacetamide Derivatization of Sulfhydryl Groups of Peptides. Journal of Mass Spectrometry.", Journal of Mass Spectrometry 42 (2007) 233-243. , 42.
V. Witte , L. Abrell , A. B. Attygalle , X. Wu, and J. Meinwald. (2007). "Structure and function of Dufour gland pheromones from the crazy ant Paratrechina longicornis. Chemoecology.", Chemoecology 17 (2007) 63-69, 17.
V. Witte, A. B. Attygalle, and J. Meinwald. (2007). "Complex Chemical Communication in the Crazy Ant Paratrechina longicornis Latreille (Hymenoptera: Formicidae). Chemoecology.", Chemoecology 17 (2007) 57-72.
Jason B. Bialecki, Frank U. Axe, and Athula B. Attygalle. "Hydroxycarbonyl anion (m/z 45), a diagnostic marker for α-hydroxy carboxylic acids", Journal of Mass Spectrometry 44 (2009) 252-259, John Wiley & Sons.
Book Chapters
Julius Pavlov and Athula B. Attygalle. (Jan 1, 2012). "LASER IONIZATION MASS SPECTROMETRY OF INORGANIC IONS", Applied Mass Spectrometry Handbook, Mike Lee , Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods, 1207-1227.
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"Biosynthetic Studies of Platensimycin Kithsiri B. Herath,, Athula B. Attygalle, Sheo B. Singh. Journal of the American Chemical Society 129 (2007) 15422-15423.".
Synthesis of Positively Charged Silver Nanoparticles via Oxidative Photoreduction of AgNO3 and Branched Polyethyleneimine in HEPES Solutions. Siliu Tan, Melek Erol, Athula Attygalle, Henry Du , and Svetlana Sukhishvili. Langmuir 23 (2007) 9836-9843.
Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor nutria) by GC-MS and GC-IR. J. Chromatogr. A 1165 (2007) 136-143.
Synthesis of [2,3,4,5,6-2H5]phenyl glucosinolateJournal of Labelled Compounds and Radiopharmaceuticals 50 (2007) 711–715.
Low-energy collision-induced fragmentation of negative ions derived from ortho-, meta-, and para-hydroxyphenyl carbaldehydes, ketones, and related compounds. J. Mass Spectrom. 42 (2007) 1207–1217.
Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major. J. Peptide Sci. 13 (2007) 445 - 450.
Hydroquinones from defensive secretion of a giant Pacific millipede, Acladocricus setigerus (Diplopoda: Spirobolida) Chemoecology 17 (2007) 131-138.
Biosynthesis of tiglic, ethacrylic and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus (Carabidae). J. Chem. Ecol 33 (2007) 1573-1561.
48 (2007). "Surface modification of protein nanocontainers and their self-directing character in polymer blends. Polymer 3632-3640. ".
J. Mass Spectrom. 42 (2007) 233-243.. "LC/MS Characterization of Undesired Products Formed During Iodoacetamide Derivatization of Sulfhydryl Groups of Peptides. ".
"Structure and function of Dufour gland pheromones from the crazy ant Paratrechina longicornis. Chemoecology 17 (2007) 63-69".
17 (2007). "Complex Chemical Communication in the Crazy Ant Paratrechina longicornis Latreille (Hymenoptera: Formicidae). Chemoecology 57-72.".
"An unprecedented ortho effect in mass spectrometric fragmentation of even-electron negative ions from hydroxyphenyl carbaldehydes and ketones Tetrahedron Lett. 47 (2006) 4601-4603. [Corrigendum: Tetrahedron Letters 48 (2007) 3485]".
"An Unprecedented Rearrangement in Collision-Induced Mass Spectrometric Fragmentation of Protonated Benzylamines. J. Mass Spectrom. 41 (2006) 1195-1204".
"Contents of the hypertrophied postpharyngeal gland of workers and soldiers of the fire ant Solenopsis geminata (Hymenoptera: Myrmicinae). Sociobiology, 47 (2006) 471-482 ".
"An Unexpected Ion-Molecule Adduct in Negative-Ion Collision-induced Decomposition (CID) Ion-Trap Mass Spectra of Halogenated Benzoic Acids . Rapid. Comm. Mass Spectrom. 20 (2006) 2265-2270.".
M. Haribal, J. A. A. Renwick, A. B. Attygalle, and D. Kiemle. (2006). "A feeding stimulant for Manduca sexta from Solanum surattenses. ", J. Chem. Ecol. 32 (2006).
Jason B. Bialecki, Frank U. Axe, and Athula B. Attygalle. (Feb 1, ). "Hydroxycarbonyl anion (m/z 45), a diagnostic marker for α-hydroxy carboxylic acids", Journal of Mass Spectrometry , 44 252-259.
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