|
|
 |
|
|
|
|
| back |
| Philip L. Leopold | |  |
 | | Philip L. Leopold | | Professor & Department Director, CCBBME | | | | |
| Close
CH 281:Biology and Biotechnology
Biological principles and their physical and chemical aspects are explored at the cellular and molecular level. Major emphasis is placed on cell structure, the processes of energy conversion by plant and animal cells, genetics and evolution, and applications to biotechnology. |
|
Close
CH 484:Introduction to Molecular Genetics
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations. |
|
Close
CH 662:Separation Methods in Analytical and Organic Chemistry
An advanced course applying principles and theory to problems in chemical analysis. Theory of separations, including distillation, chromatography, and ultracentrifugation; heterogeneity and surface effects; and sampling and its problems. |
|
Close
CH 781:Selected Topics in Biochemistry II
Topics of current interest in biochemical research are discussed, such as: enzyme chemistry, biochemical genetics and development, cellular control mechanism, biochemistry of cell membranes, bioenergetics, and microbiology.
|
|
|
| | School: Schaefer School of Engineering & Science | | Department: Chemistry, Chemical Biology & Biomedical Engineering | Program: Chemistry & Chemical Biology / Biomedical Engineering
|
|
|
| | Research & Education | |
| | Education | | Georgetown University, B.S Biology 1987 University of Texas Southwestern Medical Center, Ph.D. Neuroscience, 1993 Columbia University College of Physicians and Surgeons, Aaron Diamond Post-Doctoral Fellow, 1993-1996 |
| | | Research | | Intracellular trafficking of viruses Gene therapy Genetic diseases |
| |
| | Experience & Service | |
| | Institutional Service | - Faculty Mentor, Stevens Men's Soccer Team
- Member, Student Faculty Alliance
|
| | | Appointments | Stevens Institute of Technology - Professor and Director, Department of Chemistry, Chemical Biology, & Biomedical Engineering, 2008 - present
| | Experience | Weill Cornell Medical College, New York, NY - Assistant Professor of Biochemistry in Medicine, 1996-2004
- Assistant Professor of Genetic Medicine, 2000-2004
- Associate Professor of Genetic Medicine, 2004-2008
- Associate Professor of Biochemistry in Medicine, 2004-2008
| | Innovation and Entrepreneurship | - Mentor, Technogenesis Scholars
|
| |
| | Achievements & Professional Societies | |
| | Honors & Awards | | Georgetown University Biology Medal, 1987 Weill Medical College Excellence in Teaching Award, 2002 Weill Medical College Charles L. Bardes Teaching Prize, 2005 Edwin "Doc" Farrell Award (Stevens Institute of Technology), 2011-2 | | Grants, Contracts & Funds | | "Rigid cationic carotenoid lipids as novel miRNA delivery vectors." Collaboration with Prof. Michael Pungente, Weill Cornell Medical College - Qatar, Doha, Qatar, and Profs. Vassilia Partali and Richard Sliwka, Norwegian University of Science and Technology, Trondheim, Norway. Funding agency: Qatar National Research Foundation. "Math Science Partnership Proposal 2010: Curriculum Topic Study to Enhance Achievement in Mathematics and Science (C-TEAMS)." Collaboration with Mercedes McKay, Stevens Center for Innovation in Engineering and Science Education. Funding agency: US Department of Education/New Jersey Department of Education. "Pfizer Undergraduate Research Endeavors: Research Funding for the Technogenesis Scholarship Program." Funding agency: Independent College Fund of New Jersey/Pfizer Foundation. "Pfizer Undergraduate Research Endeavors: A Pilot Research Spine to Extend Experiential Learning Throughout the Science Curriculum." Funding agency: Independent College Fund of New Jersey/Pfizer Foundation. |
| | | Patents & Inventions | | Crystal RG, Sato N, Leopold PL. Method of modulating hair growth. United States Patent #6,159,950. | | Professional Societies | | New York Society of Experimental Microscopists, President, 2001-2003 Harvey Society, 2003-present American Society for Gene Therapy, Education Committee Chair, 2006-2008; Member, Chemical Gene Transfer Committee, American Society of Gene and Cell Therapy, 2012-present |
| |
| | Selected Publications | |
| Journals
Leopold PL, Vincent J, Wang H.. (2012). "A comparison of epithelial-to-mesenchymal transition and re-epithelialization. ", Seminars in Cancer Biology, (in press).
Pungente MD, Jubeli E, Øpstad C, Al-kawaz M, Barakat N, Ibrahim T, Khalique NA, Jones R, Leopold PL, Sliwka HR, Partali V.. (2012). "Synthesis and preliminary investigations towards the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids. ", Molecules, 17 3484-3500.
Leopold PL,* O’Mahony MJ,* Lian XJ,* Harvey BG, Crystal RG. (2009). "Smoking is associated with shortened airway cilia ", PLoS ONE, [* - these authors contributed equally to the work]. 4 (12), e8157.
Vincent T, Neve EPA, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.. (2009). "A Snail-Smad transcriptional repressor complex promotes TGF-β-mediated epithelial-mesenchymal transition ", Nature Cell Biology, 11 943-950.
Berth SB, Leopold PL, Morfini G.. (2009). "Virus-induced neuronal dysfunction and degeneration. ", Frontiers in Bioscience, 14 5239-5259.
Kiuru M, Hidaka C, Hubner R-H, Krause A, Leopold PL, Crystal RG.. (2009). "Transient systemic overexpression of Sonic hedgehog mediates expansion of diaphyseal trabecular bone with associated amplification of the hematopoietic stem cell niche.", Molecular Therapy, 17 1442-1452.
Hubner R-H, Kiuru M, Krause A, Leopold PL, Crystal RG.. (2009). "Dysfunction in glycogen storage with metabolic consequences in a mouse model of Alpha 1-Antitrypsin Deficiency", Am. J. Resp. Cell Molec. Biol., 40 239-247.
Saitoh H, Leopold PL, Harvey B-G, O'Connor TP, Worgall S, Hackett NR, Crystal RG. (2009). "Emphysema Mediated by Lung Overexpression of ADAM10", Clin Transl Sci, 2 50-56.
Song Y, Lou HH, Boyer JL, Limberis MP, Vandenberghe LH, Hackett NR, Leopold PL, Wilson JM, Crystal RG. (2009). "Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing", Hum Gene Ther, 20 267-281.
Leopold PL, Crystal RG. (2007). "Intracellular trafficking of adenovirus: Many means to many ends", Advanced Drug Delivery Reviews, 59 810-821.
Leopold PL, Wendland R, Vincent T, Crystal RG. (2006). "Neutralized adenovirus-immune complexes can mediate effective gene transfer via a Fc receptor-dependent infection pathway", Journal of Virology, 80 10237-10247.
Leopold PL, Pfister KK. (2006). "Viral strategies for intracellular trafficking: motors and microtubules", Traffic, 7 516-523.
Kelkar S, De B, Gao G, Wilson JM, Crystal RG, Leopold PL. (2006). "A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes", Journal of Virology, 80 7781-7785.
Lou H, Crystal RG, Leopold PL. (2005). "Enhanced in vivo efficacy of cholesterol-minus Sonic hedgehog", Molecular Therapy, 12 575-578.
Conference Proceedings
Leopold PL. (2007). "Viruses as Mentors for Nano-scale Drug Delivery", Eighth Annual Nanobiotechnology Symposium. Cornell University Nanobiotechnology Center.
Book Chapters
Leopold PL. (2007). "Chapter 34: Microtubule-dependent motility during intracellular trafficking of vector genome to the nucleus: Subcellular mimicry in virology and nanoengineering", Nanotechnology in Biology and Medicine, T. Vo-Dinh, Taylor and Francis, Inc./CRC Press Inc., London.
|
|
| |
|
|
|
|
|
|
|
