Dr. Yu's research focuses on tissue engineering, polymeric biomaterials and drug delivery. His current research activities include nano- and micro-scale functionalization of biomimic three-dimensional (3D) scaffolds for neural and musculoskeletal tissue repair and regeneration, investigation of cell and material interactions in 2D, 3D and in bioreactors, development of controlled release systems for the delivery of growth factors and drugs, and manipulation of the microenvironment for stem cell proliferation and differentiation.
Dr. Yu is a member of the Society for Biomaterials, and the Materials Research Society. He is known as an innovator in the Tissue Engineering field, has contributed many journal articles and conference proceedings, and recently received a grant from the National Institute of Health (NIH) for his work involving development of nerve grafts that promote rapid re-growth due to improved scaffolding on the neural tissue engineering frontier. He has also received the Early Career Translational Research Award in Biomedical Engineering (Phase I & Phase II) from the Wallace H. Coulter Foundation, and research grant from the AO Foundation for supporting his work in developing novel tissue engineered scaffolds for improving bone healing. |
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Chandra M. Valmikinathan, Junping Wang, Sergio Smiriglio, Neha G. Golwala, and Xiaojun Yu.. (2009). Magnetically induced protein gradients on electrospun nanofibers, Combinatorial Chemistry & High Throughput Screening (In Press)
Nebahat Degirmenbasi, Seher Ozkan, Dilhan M. Kalyon and Yu, X.. (2009). Surface patterning of poly (L-lactide) upon melt processing: in vitro culturing of fibroblasts and osteoblasts on surfaces ranging from highly crystalline with spherulitic protrusions to amorphous with nanoscale indentations, Journal of Biomedical Materials Research PartA. . 88 (1), 94-104
Seher Ozkan, Dilhan M. Kalyon and Yu, X.. (2009). Functionally graded TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering (In Press), Journal of Biomedical Materials Research Part A
Chandra M Valmikinathan, Jingjing Tian, Junping Wang, and Yu X. (2008). Novel nanofibrous spiral scaffolds for neural tissue engineering, Journal of Neural Engineering. 5 422-432
Laurencin CT, Khan Y, Kofron M, El-Amin S, Botchwey E, Yu X, Cooper JA Jr. (2006). The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective (review), Clin Orthop Relat Res. , 447 221-236
X. Yu, E.A. Botchwey, E.M. Levine, S.R. Pollack and C.T. Laurencin.. (2004). Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotype expression and matrix mineralization, Proc Natl Acad Sci USA. 101 (31), 11203-8
X. Yu and R.V. Bellamkonda.. (2003). Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps, Tissue Engineering. 9 (3), 421-430
N.J. Meilander, X. Yu, N.P. Ziats and R.V. Bellamkonda. (2001). Lipid-based microtubular drug delivery vehicles, J Control Release. 71 (1), 141-152
A.P. Balgude, X. Yu, A. Szymanski and R.V. Bellamkonda. (2001). Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures, Biomaterials. 22 (10), 1077-1084
X. Yu and R.V. Bellamkonda. (2001). Dorsal root ganglia neurite extension across mechanical and charged interfaces, Journal of Neuroscience Research, (66), 303-310
Y. Zhong, X. Yu, R. Gilbert, R.V. Bellamkonda. (2001). Stabilizing electrode-host interfaces: a tissue engineering approach, Journal of Rehabilitation Research and Development, 38 (6), 627-632
D.A. Eavarone, X. Yu and R.V. Bellamkonda. (2000). Receptor-mediated targeting of C6 glioma by transferrin-coupled liposomes, Journal of Biomedical Materials Research, 51 (1), 10-14
G.P. Dillon, X. Yu and R.V. Bellamkonda. (2000). The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs, Journal of Biomedical Materials Research, 51 (3), 510-519
X. Yu, G.P. Dillon and R.V. Bellamkonda. (1999). A laminin and nerve growth factor laden 3D matrix for enhanced neurite extension, Tissue Engineering. 5 (4), 291-304
G.P. Dillon, X. Yu, A. Sridharran, J.P. Ranieri and R.V. Bellamkonda. (1998). The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold, Journal of Biomaterials Science: Polymer Edition 9, 1015-1114
Yu. X, Chandra M. Valmikinathan, Junping wang, Amanda Rogers and John Hoffman. (2009). Electrospun nanofibers for bioengineering applications (In Press), “Encyclopedia of Nanoscience and Nanotechnology” (second edition), Nalwa HS, American Scientific Publishers
Yu, X., Chandra Valmikinathan, Amada Rogers and Junping Wang.. (2007). Nanotechnology based drug delivery, Biomedical nanostructures, Gonsalves KE, Laurencin CT, Halberstadt C, Nair LS, John Wiley & Sons, Inc. . 91-112
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