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Professor Leopold focuses his research on gene therapy - viral mimics, host - virus interactions, and gene expression in human disease.
He is an integral researcher in the field of Tissue Engineering, implementing the use of nanotechnology to revolutionize approaches for skin grafting, bone, nerve and cardiac cell regeneration.
Dr. Leopold Prof recently received funding to study "Rigid cationic carotenoid lipids as novel miRNA delivery vectors." In this role he will serve as Co-Principal on this project funded by the Qatar National Research Fund. The proposal will provide Prof. Leopold with $243,000 to support evaluation of new gene delivery vectors.
He has been awarded a patent for his invention “Crystal RG, Sato N, Leopold PL. Method of modulating hair growth. United States Patent #6,159,950”. He is a member of the New York Society of Experimental Microscopists, the Harvey Society, and the American Society for Gene Therapy, Education Committee Chair. Honors and awards have included the Georgetown University Biology Medal, Weill Medical College Excellence in Teaching Award, and Weill Medical College Charles L. Bardes Teaching Prize. |
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Song Y, Lou HH, Boyer JL, Limberis MP, Vandenberghe LH, Hackett NR, Leopold PL, Wilson JM, Crystal RG. (2009). Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing, Hum Gene Ther, 20 267-281
Leopold PL,* O’Mahony MJ,* Lian XJ,* Harvey BG, Crystal RG. (2009). Smoking is associated with shortened airway cilia, PLoS ONE, [* - these authors contributed equally to the work]. 4 (12), e8157
Berth SB, Leopold PL, Morfini G.. (2009). Virus-induced neuronal dysfunction and degeneration, Frontiers in Bioscience, 14 5239-5259
Kiuru M, Hidaka C, Hubner R-H, Krause A, Leopold PL, Crystal RG.. (2009). Transient systemic overexpression of Sonic hedgehog mediates expansion of diaphyseal trabecular bone with associated amplification of the hematopoietic stem cell niche, Molecular Therapy, 17 1442-1452
Vincent T, Neve EPA, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.. (2009). A Snail-Smad transcriptional repressor complex promotes TGF-β-mediated epithelial-mesenchymal transition, Nature Cell Biology, 11 943-950
Hubner R-H, Kiuru M, Krause A, Leopold PL, Crystal RG.. (2009). Dysfunction in glycogen storage with metabolic consequences in a mouse model of Alpha 1-Antitrypsin Deficiency, Am. J. Resp. Cell Molec. Biol., 40 239-247
Saitoh H, Leopold PL, Harvey B-G, O'Connor TP, Worgall S, Hackett NR, Crystal RG. (2009). Emphysema Mediated by Lung Overexpression of ADAM10, Clin Transl Sci, 2 50-56
Leopold PL, Crystal RG. (2007). Intracellular trafficking of adenovirus: Many means to many ends, Advanced Drug Delivery Reviews, 59 810-821
Leopold PL, Pfister KK. (2006). Viral strategies for intracellular trafficking: motors and microtubules, Traffic, 7 516-523
Leopold PL, Wendland R, Vincent T, Crystal RG. (2006). Neutralized adenovirus-immune complexes can mediate effective gene transfer via a Fc receptor-dependent infection pathway, Journal of Virology, 80 10237-10247
Kelkar S, De B, Gao G, Wilson JM, Crystal RG, Leopold PL. (2006). A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes, Journal of Virology, 80 7781-7785
Lou H, Crystal RG, Leopold PL. (2005). Enhanced in vivo efficacy of cholesterol-minus Sonic hedgehog, Molecular Therapy, 12 575-578
Leopold PL. (2007). Chapter 34: Microtubule-dependent motility during intracellular trafficking of vector genome to the nucleus: Subcellular mimicry in virology and nanoengineering, Nanotechnology in Biology and Medicine, T. Vo-Dinh, Taylor and Francis, Inc./CRC Press Inc., London
Leopold PL. (2007). Viruses as Mentors for Nano-scale Drug Delivery, Eighth Annual Nanobiotechnology Symposium. Cornell University Nanobiotechnology Center
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