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Dr. Perlman’s laboratory studies lung mechanics in the context of acute lung injury. One of the hallmarks of acute lung injury is pulmonary edema, where liquid leaks out of the blood vessels into the airspace of the lung. This liquid-filling of the airspace causes patients to have difficulty breathing.
For breathing assistance, patients with acute lung injury are treated with mechanical ventilation. In providing sufficient gas exchange, however, mechanical ventilation can cause over-distension injury of the lungs and prevent recovery. The mortality rate is about 30% and patients often die from the ventilator injury, not the underlying lung disease.
To address this problem, her research analyzes the inflation mechanics of the edematous lung. The goal is to use her understanding of mechanics to inform development of novel treatment methods that reduce ventilator induced lung injury. |
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Kuo AS, Perlman CE, Mockros LF, Cook KE. (2008). Pulmonic valve function during thoracic artificial lung attachment, ASAIO Journal, (54), 197
Perlman CE, Mockros LF. (2007). Hemodynamic consequences of thoracic artificial lung attachment configuration: a computational model, ASAIO Journal, (53), 50
Lindert J, Perlman CE, Parthasarathi K, Bhattacharya J. (2007). Chloride-dependent secretion of alveolar wall liquid determined by optical sectioning microscopy, American Journal of Respiratory Cell and Molecular Biology, (36), 688
Perlman CE and Bhattacharya J. (2007). Alveolar expansion imaged by optical sectioning microscopy, Journal of Applied Physiology, (103), 1037
Perlman CE, Cook KE, Seipelt R, Mavroudis C, Backer CL, Mockros LF. (2005). In vivo hemodynamic responses to thoracic artificial lung attachment, ASAIO Journal, (51), 412
Cook KE, Perlman CE, Seipelt R, Backer CL, Mavroudis C, Mockros LF. (2005). Hemodynamic and gas transfer properties of a compliant thoracic artificial lung, ASAIO Journal , (51), 404
Boschetti F, Cook KE, Perlman CE, Mavroudis LF, Backer CL, Mockros LF. (2003). Blood flow pulsatility effects upon oxygen transfer in artificial lungs, ASAIO Journal , (49), 678
Boschetti F, Perlman CE, Cook KE, Mockros LF. (2000). Hemodynamic effects of attachment modes and device design of a thoracic artificial lung, ASAIO Journal , (46), 42
Perlman CE, Lederer DJ, Bhattacharya J. The micromechanics of alveolar edema, American Journal of Respiratory Cell and Molecular Biology. In Press
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