Pharmacodynamics and Pharmacokinetics on a Chip

Friday, October 11, 2013 ( 2:00 pm to 3:00 pm )

Location: Babbio 310, Stevens Institute of Technology

Contact: 
Nancy Webb, nwebb@stevens.edu

Jong Wook Hong

Department of Mechanical Engineering

Auburn University, USA

ABSTRACT

Cell-based efficacy tests are critical for discovering new drugs and confirming other functionalities with existing drugs. Conventionally, for cytotoxicity tests, cells are cultivated in Petri dishes, tubes, or microcell-plates, and incubated with different reagents that are distributed over wide ranges of concentrations. In this lecture, novel microfluidic systems for the determination of cell-based half maximum inhibition concentrations or IC50 values of different chemicals will be discussed through the formation of wide range of concentration gradients. The system and methodology could be applied to many other biochemical and biomedical analyses such as determination of kinetic parameters of enzymatic reactions and binding constants of proteins and peptides, which opens new windows in pharmacodynamics and pharmacokinetics.

BIOGRAPHY

Jong Wook Hong is currently an associate professor in the Department of Mechanical Engineering at Auburn University.  He has been appointed as a visiting professor of Pharmacy at Seoul National University and a professor of Bionano Engineering at Hanyang University, Korea. Hong has published in various scientific journals including Science and Nature Biotechnology.  Hong’s research interests cover BioMEMS/NEMS; biomaterials; automated high-throughput systems for synthetic biology; biomolecular engineering; and nanoparticle synthesis.  He received his Ph.D. in Chemical Engineering from The University of Tokyo as a Japanese Government Fellow (Monbusho Scholar). During and after his doctorate research, he worked at the Institute of Physical and Chemical Research (RIKEN), Japan, and at the Institute of Industrial Science (IIS), The University of Tokyo. Before joining Auburn in 2004 as an assistant professor, he was a postdoctoral scholar at the T.J. Watson, Sr. Laboratories of Applied Physics of The California Institute of Technology (Caltech), Pasadena, CA, USA.