Development of Advanced Optofluidic Biological and Chemical Sensors

Monday, December 2, 2013 ( 2:00 pm to 3:00 pm )

Location: Kidde 360, Stevens Institute of Technology

Nancy Webb,

Dr. Maung (Malcolm) Khaing Oo

University of Michigan

Department of Biomedical Engineering



Optofluidics—integration of photonics and microfluidics—is an emerging technology in biological /chemical analysis and acquires unique characteristics for sensing that are not capable with other types of sensors. Rapid and ultra-sensitive sensors are demanded in a broad range of applications such as detection of drugs at point-of-care in clinical settings, rapid identification of hazardous chemicals in environmental monitoring, and explosive-constituent vapor detection in homeland security operations. Furthermore, quantifying specific analytes at low concentration in complex liquid mixtures is essential in hospitals and industrial/research labs. However, a traditional powerful method of enzyme linked immunosorbent assay (ELISA) experiences from a few major drawbacks—inadequate detection limit, long testing time, and large sample/reagent consumption. This talk will be focused on fundamental, design, and development of optofluidic biological and chemical sensors for society’s needs and potential commercialization. In particular, I will emphasize on two major research areas: (1) Optofluidic Surface-enhanced Raman Scattering (SERS); and (2) Optofluidic ELISA.



Maung (Malcolm) Khaing Oo is currently a senior research fellow at the Department of Biomedical Engineering, University of Michigan. His research activities include development of a new generation optofluidic ELISA well-plate, photonic crystal fiber and structure for ultra-sensitive detection and identification, nanotechnology-enabled SERS, targeted drug delivery, and enhanced generation of reactive species during Photodynamic Therapy of cancer to improve specific cancer treatment. He has published 18 papers in peer-reviewed journals including three in ACS Nano and one in Advanced Materials, and several papers in conference proceedings. He received his Ph.D. in Materials Engineering from the Stevens Institute of Technology.  Prior to the Stevens, he received his M.S. from the National University of Singapore and his B.S. from the Yangon University.