Applied Spectroscopy: Shedding Light on Problems in Pharmaceutical Development

Friday, November 1, 2013 ( 2:00 pm to 3:00 pm )

Location: Babbio 310, Stevens Institute of Technology

Contact: 
Nancy Webb, nwebb@stevens.edu

Timothy A. Rhodes
Pharmaceutical Sciences & Clinical Supply
Merck & Co., Inc. Rahway, NJ
ABSTRACT
Advances in the power of spectroscopic tools have resulted in significant changes in our understanding of materials, both in solution phase behavior and in the solid state. These advances in power along with significant improvements in robustness and ease of use have also led to an increased emphasis on spectroscopic tools in the pharmaceutical industry where conventional HPLC based assays are being challenged by non-destructive techniques that can provide insights into material properties in its native environment. Many of these tools have evolved from their roots in academic research to become completely automated, hands-free technologies. And some of these tools have started to make in-roads into 2D and 3D imaging.
In this talk, I will discuss a number of spectroscopic techniques as they are applied to issues important to pharmaceutical research and development including process development challenges, understanding material properties, and mechanisms of physical and chemical transformation. The technologies discussed will include solid state NMR, X-ray diffraction, Raman spectroscopy and Raman chemical imaging among many others.
BIOGRAPHY
Tim Rhodes is a Senior Principal Scientist at Merck & Co., Inc. located in Rahway, NJ. His group focuses on the development and implementation of automation technologies incorporating advanced robotics and analytical tools and methodologies to drive increases in productivity and a deeper understanding of pharmaceutical processes and material characterization. Analytical methods include high throughput HPLC, UPLC, XRD, Raman spectroscopy and microscopy, dynamic light scattering, UV/Vis absorbance, and fluorescence. His interests also include the application of mathematical models to extract more insight from the vast quantities of data that are collected on compounds in discovery and development.
Dr. Rhodes received his B.S. in Chemistry in 1991 from New York University. He received his PhD from the University of Texas at Austin in 1996 in Organic Chemistry studying reaction dynamics in supercritical fluids. Before joining Merck in 1999, his post-doctoral research focused on charge transfer complexes in amorphous solids at the NSF Center for Photo-induced Charge Transfer Studies at the University of Rochester.