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| | (3-0-3) (Lec-Lab-Credit Hours)
Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Imaging plays a critical role in both clinical and research environments. This course presents both the basic physics and the practical technology associated with such methods as X-ray computed tomography (CT), magnetic resonance imaging (MRI), functional MRI (f-MRI) and spectroscopy, ultrasonics (echocardiography, doppler flow), nuclear medicine (Gallium, PET and SPECT scans) and optical methods such as bioluminescence, optical tomography, fluorescent confocal microscopy, two-photon microscopy and atomic force microscopy.
Prerequisites:
E 232 Engineering Design IV
(2-3-3)(Lec-Lab-Credit Hours)
This course continues the experiential sequence in design. Design projects are in, and lectures address the area of Electronics and Instrumentation. Core design themes are further developed.
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Introduction to Bioengineering
(3-0-3)(Lec-Lab-Credit Hours)
Overview of the biomedical engineering field with applications relevant to the healthcare industry such as medical instrumentation and devices. Introduction to the nervous system, propagation of the action potential, muscle contraction and introduction to the cardiovascular system. Discussion of ethical issues in biomedicine.
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Engineering Design VI
(1-3-2)(Lec-Lab-Credit Hours)
Introduction to the principles of wireless transmission and the design of biomedical devices and instrumentation with wireless capabilities.(e.g. pacemakers, defibrilators. EKG). Electrical safety (isolation, shielding), and equipment validation standards for FDA compliance are introduced. Use of LabView to provide virtual bioinstrumentation. The course culminates in group projects to design a biomedical device that runs on wireless technology.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Intended as an introduction to materials science for biomedical engineers, this course first reviews the properties of materials relevant to their application to the human body. It goes on to discuss proteins, cells, tissues and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs and elements of tissue engineering.
Corequisites:
BME 506 Biomechanics
(3-0-3)(Lec-Lab-Credit Hours)
This course reviews basic engineering principles governing materials and structures such as mechanics, rigid body dynamics, fluid mechanics and solid mechanics and applies these to the study of biological systems such as ligaments, tendons, bone, muscles, joints, etc. The influence of material properties on the structure and function of organisms provides an appreciation for the mechanical complexity of biological systems. Methods for both rigid body and deformational mechanics are developed in the context of bone, muscle and connective tissue. Multiple applications of Newt
on's Laws of Mechanics are made to human motion.
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Prerequisites:
E 344 Materials Processing
(3-0-3)(Lec-Lab-Credit Hours)
An introduction is provided to the important engineering properties of materials, to the scientific understanding of those properties and to the methods of controlling them. This is provided in the context of the processing of materials to produce products.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course reviews basic engineering principles governing materials and structures such as mechanics, rigid body dynamics, fluid mechanics and solid mechanics and applies these to the study of biological systems such as ligaments, tendons, bone, muscles, joints, etc. The influence of material properties on the structure and function of organisms provides an appreciation for the mechanical complexity of biological systems. Methods for both rigid body and deformational mechanics are developed in the context of bone, muscle and connective tissue. Multiple applications of Newton's Laws of Mechanics are made to human motion.
Corequisites:
BME 505 Biomaterials
(3-0-3)(Lec-Lab-Credit Hours)
Intended as an introduction to materials science for biomedical engineers, this course first reviews the properties of materials relevant to their application to the human body. It goes on to discuss proteins, cells, tissues and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs and elements of tissue engineering.
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Prerequisites:
BME 342 Transport in Biological Systems
(3-3-4)(Lec-Lab-Credit Hours)
A study of momentum, mass and heat transport in living systems. Rheology of blood. Basic hemodynamics. Use of the equations of continuity and motion to set up complex flow problems. Flow within distensible tubes. Shear stress and endothelial cell function. Mass transfer and metabolism in organs and tissues. Microscopic and macroscopic mass balances. Diffusion. Blood-tissue transport of solutes in the microcirculation. Compartmental models for pharmacokinetic analyses. Analysis of blood oxygenators, hemodialysis, tissue growth in porous support materials. Artificial organs. Energy balances and the use of heat to treat tumor growth (radio frequency ablation, cryogenic ablation). Laboratory exercises accompany major topics discussed in class and are conducted at the same time.
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| Course focuses on speech, audition, and vision systems. Students will begin with a review of system principles including sampling, filtering, analog to digital conversion (ADC), spectral (Fourier) analysis and transfer functions. The second topic will cover the audio spectrum and properties of sound as they relate to both speech and hearing. The course will then cover basic anatomy and physiology of the larynx, ear, and eye. Students will participate in two types of Labs for each of the three topics. Sensory Labs are designed to enhance the students’ knowledge of sound production, auditory response and image processing. Reverse Engineering (RE) Labs utilizing existing speech, hearing, and vision enhancement products will be conducted as well.
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| A successful approach to product development and design in the field of medical technologies requires a highly interdisciplinary approach. This course reviews the regulations, protocol, and guidelines which must be met in each discipline, and describes how these issues are inter-related and how they affect design and product development. Marketing, regulatory, IP, and clinical aspects are all considered in the technical aspects of design. Required of all BME M.E. students.
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| | (0-0-0) (Lec-Lab-Credit Hours)
One of the distinguishing features of biomedical engineers is the ability to make and interpret measurements on living systems. One of the major objectives of advanced laboratory training is to provide experience in selecting appropriate measurement and analysis tools that will advance hypothesis driven and translational research and development. This laboratory course serves these dual purposes. Students are introduced to techniques for measurements at the cellular, organ and systems levels. Students will then use these techniques to: (1) formulate hypotheses, design experiments using the tools provided, make appropriate measurements, analyze the data and determine if the data do or do not support their hypotheses and (2) make measurements that facilitate the design and manufacture of devices in terms of materials properties, fatigue and failure modes.
Prerequisites:
BME 505 Biomaterials
(3-0-3)(Lec-Lab-Credit Hours)
Intended as an introduction to materials science for biomedical engineers, this course first reviews the properties of materials relevant to their application to the human body. It goes on to discuss proteins, cells, tissues and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs and elements of tissue engineering.
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Physiological Systems
(3-0-3)(Lec-Lab-Credit Hours)
Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis.
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| This course is an introduction to the field of Tissue Engineering. It is rapidly emerging as a therapeutic approach to treating damaged or diseased tissues in the biotechnology industry. In essence, new and functional living tissue can be fabricated using living cells combined with a scaffolding material to guide tissue development. Such scaffolds can be synthetic, natural, or a combination of both. This course will cover the advances in the field of cell biology, molecular biology, material science, and their relationship towards developing novel ‘tissue engineered’ materials.
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| The engineering applications of biological transport phenomena are important considerations in basic research related to molecules, organelles, cell, and organ function; the design and operation of devices such as filtration units for kidney dialysis, high density cell cultures, and biosensors; and applications including drug and gene delivery, biological signal transduction, and tissue engineering. This course develops the fundamental principles of transport processes, the mathematical expression of these principles and the solution of transport equations, along with characterization of composition, structure, and function of the living systems to which they are applied.
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| This course extends concepts presented in tissue engineering, bio-transport, and biomaterials to develop design principles for generating tissue and organs in vitro. The processes by which cells, proteins, and extracellular matrix are integrated to form a functioning organ system are developed. The principles of bioreactor design are used to analyze and design in vitro systems for growing functioning tissue and organs for use as prostheses. Principles for scale-up to organs of different size are discussed. Design issues and limitations for extension of these principles to multi-organ systems are illustrated.
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| | (0-0-3) (Lec-Lab-Credit Hours)
Pathophysiology describes changes in physiology resulting in disease or injury. A solid understanding of normal physiology is necessary before attempting the study of abnormal situations. The course emphasizes the “mechanistic” approach to pathophysiology, i.e. A-B-C, rather than symptom-diagnosis-treatment approach. Multiple examples, case studies, and procedural videos are presented with a discussion of what they do well and where improvements can be made.
Prerequisites:
CH 583 Physiology
(3-0-3)(Lec-Lab-Credit Hours)
Fundamentals of control processes governing physiological systems analyzed at the cellular and molecular level. Biological signal transduction and negative feedback control of metabolic processes. Examples from sensory, nervous, cardiovascular, and endocrine systems. Deviations that give rise to abnormal states; their detection, and the theory behind the imaging and diagnostic techniques such as MRI, PET, SPECT; and the design and development of therapeutic drugs. The principles, uses, and applications of biomaterials and tissue engineering techniques; and problems associated with biocompatibility. Students (or groups of students) are expected to write and present a term project.
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| | | (0-0-3) (Lec-Lab-Credit Hours)
This course will provide a comprehensive introduction to the rapidly developing field of nanomedicine and discuss the application of nanoscience and nanotechnology in medicine such as, in diagnosis, imaging and therapy, surgery, and drug delivery.
Prerequisites:
NANO 600
(0-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (0-0-3) (Lec-Lab-Credit Hours)
This course describes the application of nano- and micro-fabrication methods to build tools for exploring the mysteries of biological systems. It is a graduate-level course that will cover the basics of biology and the principles and practice of nano- and microfabrication techniques, with a focus on applications in biomedical and biological research.
Prerequisites:
NANO 600
(0-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This advanced course covers the mechanism and biological role of signal transduction in mammalian cells. Topics included are extracellular regulatory signals, intracellular signal transduction pathways, role of tissue context in the function of cellular regulation, and examples of biological processes controlled by specific cellular signal transduction pathways.
Prerequisites:CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course deals with the principles of light interactions with biological- and biomedical-relevant systems. The enabling aspects of nanotechnology for advanced biosensing, medical diagnosis, and therapeutically treatment will be discussed.
Prerequisites:
NANO 600
(0-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Lectures
by department faculty, guest speakers. and doctoral students on recent research. Enrollment during the entire period of study is required of all full-time students. No credit. Must be taken every semester.
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| Selected topics of current interest in the field of biomedical engineering will be treated from an advanced point of view.
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| One to three credits. Limit of three credits for the degree of Master of Engineering (Biomedical).
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| For the degree of Master of Engineering (Biomedical). Nine credits with departmental approval
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| Design project for the degree of Master of Engineering (Biomedical). Hours to be arranged. Six credits, with departmental approval.
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| Original research leading to the doctoral dissertation. Hours and credits to be arranged.
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| Chemistry & Chemical Biology |
| Review of undergraduate physical chemistry by means of problem solving; atomic spectra; structure of atoms and molecules; thermodynamics; changes of state; solutions; chemical equilibrium; kinetic theory of gases; chemical kinetics, and electrochemistry. This course may not be counted toward the master's degree and is not open to undergraduate students.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The elements of quantum mechanics are developed and applied to chemical systems. Valence bond theory and molecular orbital theory of small molecules; introduction to group theory for molecular symmetry; fundamental aspects of chemical bonding, and molecular spectra.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Lectures, demonstrations, and laboratory experiments, selected from among the following topics, depending on student interest: vacuum technology; thin-film preparation; scanning electron microscopy; infrared spectroscopy and ellipsometry; electron spectroscopy
; Auger, photoelectron, and LEED; ion spectroscopies; SIMS, IBS, and field emission; surface properties-area, roughness, and surface tension.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems, and special operations. Prerequisite: one year of organic laboratory. Laboratory Fee: $60. Fall semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems, and special operations. Prerequisite: one year of organic laboratory. Laboratory Fee: $60. Spring semester.
Prerequisites:
CH 540 Advanced Organic Laboratory I
(3-0-3)(Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems, and special operations. Prerequisite: one year of organic laboratory. Laboratory Fee: $60. Fall semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Primarily a laboratory course, with some lecture presenting the principles and applications of contemporary instrumental analytical methods, with a focus on spectroscopy and separations. Laboratory practice explores ultraviolet, visible, and infrared spectrophotometry; atomic absorption spectroscopy; nuclear magnetic resonance spectrometry; gas-liquid and high-performance liquid chromatography, and mass spectrometry. These instrumental techniques are utilized for quantitative and qualitative analyses of organic, inorganic, biological, and environmental samples. L
aboratory fee: $60.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussions include metabolic pathways in biosynthesis and catabolism of biomolecules, including carbohydrates, proteins, lipids, and nucleic acids. The hormonal regulation of metabolism, as well as vitamin metabolism, is presented.
Prerequisites:
CH 242 Organic Chemistry II
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The relationship of the chemical and physical structure of biological macromolecules to their biological functions as derived from osmotic pressure, viscosity, light and X-ray scatting, diffusion, ultracentrifugation, and electrophoresis. The course is subdivided into: 1) properties, functions, and interrelations of biological macromolecules, e.g., polysaccharides, proteins, and nucleic acids; 2) correlation of physical properties of macromolecules in solution; 3) conformational properties of proteins and nucleic acids; and 4) aspects of metal ions in biological systems.
Prerequisites:
CH 421 Chemical Dynamics
(3-4-4)(Lec-Lab-Credit Hours)
Chemical kinetics, solution theories with applications to separation processes, electrolytes, polyelectrolytes, regular solutions and phase equilibria, and laboratory practice in the measurements of physical properties and rate processes.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Fundamentals of control processes governing physiological systems analyzed at the cellular and molecular level. Biological signal transduction and negative feedback control of metabolic processes. Examples from sensory, nervous, cardiovascular, and endocrine systems. Deviations that give rise to abnormal states; their detection, and the theory behind the imaging and diagnostic techniques such as MRI, PET, SPECT; and the design and development of therapeutic drugs. The principles, uses, and applications of biomaterials and tissue engineering techniques; and problems associated with biocompatibility. Students (or groups of students) are expected to write and present a term project.
Prerequisites:
CH 382 Biological Systems
(3-3-4)(Lec-Lab-Credit Hours)
Physiochemical principles underlying the coordinated function in multicellular organisms are studied. Electrical properties of biological membranes, characteristics of tissues, nerve-muscle electrophysiology, circulatory, respiratory, endocrine, digestive, and excretory systems are covered. Computer simulation experiments and data acquisition methods to evaluate and monitor human physiological systems are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A systematic treatment of the bonding and reactivity of inorganic substances; molecular shape and electron charge distribution of main-group and coordination compounds, including valence-bond theory and a group theoretical approach to molecular orbital theory; organometallic chemistry; the solid state; and the role of inorganic compounds in biological processes and the environment.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Applications of the laws of thermodynamics to solutions, electrolytes and polyelectrolytes, binding, and biological systems; statistical thermodynamics is developed and applied to spectroscopy and transition state theory; and chemical kinetics of simple and complex reactions, enzyme and heterogeneous catalysis, and theories of reaction rates.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Theorems and postulates of quantum mechanics; operator relationships; solutions of the Schrödinger equation for model systems; variation and perturbation methods; pure spin states; Hartree-Fock self-consistent field theory; and applications to many-electron atoms and molecules.
Prerequisites:
CH 520 Advanced Physical Chemistry
(3-0-3)(Lec-Lab-Credit Hours)
The elements of quantum mechanics are developed and applied to chemical systems. Valence bond theory and molecular orbital theory of small molecules; introduction to group theory for molecular symmetry; fundamental aspects of chemical bonding, and molecular spectra.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Theoretical foundations of spectroscopic methods and their application to the study of molecular structure and properties. Theory of the absorption and emission of radiation; line spectra of complex atoms; and group theory and rotational, vibrational, and electronic spectroscopy of diatomic and polyatomic molecules.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A detailed discussion of the kinetics and mechanism of complex reactions in the gaseous and liquid phases. Topics include stationary and nonstationary conditions; chain reactions; photo and radiation-induced reactions; and reaction rate theories.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Classical and quantum mechanical preliminaries; derivation of the laws of thermodynamics; applications to monoatomic and polyatomic gases and to gaseous mixtures; systems of dependent particles with applications to the crystalline solid, the imperfect ga, s and the cooperative phenomena; electric and magnetic fields; and degenerate gases.
Prerequisites:
CH 620 Chemical Thermodynamics and Kinetics
(3-0-3)(Lec-Lab-Credit Hours)
Applications of the laws of thermodynamics to solutions, electrolytes and polyelectrolytes, binding, and biological systems; statistical thermodynamics is developed and applied to spectroscopy and transition state theory; and chemical kinetics of simple and complex reactions, enzyme and heterogeneous catalysis, and theories of reaction rates.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course in the chemistry of carbon compounds, with special reference to polyfunctional compounds, heterocycles, techniques of literature survey, stereochemical concepts, and physical tools for organic chemists. Fall semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course in the chemistry of carbon compounds, with special reference to polyfunctional compounds, heterocycles, techniques of literature survey, stereochemical concepts, and physical tools for organic chemists. Spring semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A survey of important synthetic methods with empha
sis on stereochemistry and reaction mechanism.
Prerequisites:
CH 640 Advanced Organic and Heterocyclic Chemistry I
(3-0-3)(Lec-Lab-Credit Hours)
An advanced course in the chemistry of carbon compounds, with special reference to polyfunctional compounds, heterocycles, techniques of literature survey, stereochemical concepts, and physical tools for organic chemists. Fall semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Structure, synthesis, and biogenesis of antibiotics, alkaloids, hormones, and other natural products.
Prerequisites:
CH 242 Organic Chemistry II
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussion at the molecular level of drug receptor interaction, influence of stereochemistry and physiochemical properties on drug action, pharmacological effects of structural features, mechanism of drug action, metabolic rate of drugs in animals and man, and drug design. The application of newer physical tools and recent advances in methods for pharmacological studies will be emphasized.
Prerequisites:
CH 242 Organic Chemistry II
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An intensive course on the interpretation of spectroscopic data; emphasis is on the use of modern spectroscopic techniques, such as NMR (13C, D, 15N, and H), mass (including CI), laser-Raman, ESCA, ORD, CD, IR, and UV for structure elucidation. Special attention is given to the application of computer technology in spectral work. A course designed for practicing chemists in analytical, organic, physical, and biomedical areas. Extensive problem solving. No laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Advanced treatment of the theory and practice of spectrometric methods (mass spectrometry, nuclear magnetic resonance, etc.) and electroanalytical methods with emphasis on Fourier Transform techniques (FTIR, FTNMR, etc.) and hyphenated methods (gc-ms, etc.), the instrument-sample interaction, and signal sampling. A survey of computational methods, such as factor analysis and other chemometric methods is also included.
Prerequisites:
CH 362 Instrumental Analysis I
(3-4-4)(Lec-Lab-Credit Hours)
Experimental approach to spectroscopy. Topics include Fourier Transform infrared spectroscopy, ultraviolet, visible and fluorescence measurements, atomic absorption spectroscopy, and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests are considered in the assignment of work on one or more of the following: NMR spectrometry, mass spectrometry, electrochemical methods, infrared, ultraviolet, and visible spectrophotometry. Laboratory Fee: $60.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course applying principles and theory to problems in chemical analysis. Theory of separations, including distillation, chromatography, and ultracentrifugation; heterogeneity and surface effects; and sampling and its problems.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A practical treatment of the mechanical, electronic, and optical devices used in the construction of instruments for research and chemical analysis and control; motors, light sources and detectors, servomechanisms, electronic components and test equipment, vacuum and pressure measuring devices, and overall design concepts are among the topics treated. Laboratory fee: $60.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discusses computational chemistry topics, including energy minimization, molecular dynamics, solvation mechanics, and electronic structure calculations. Applications in drug design and receptors will be discussed.
Prerequisites:
CH 321 Theromodynamics
(3-0-3)(Lec-Lab-Credit Hours)
Laws of thermodynamics, thermodynamic functions, and the foundations of statistical thermodynamics. The chemical potential is applied to phase equilibria, chemical reaction equilibria, and solution theory, for both ideal and real systems.
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| | (3-4-4) (Lec-Lab-Credit Hours)
A comprehensive hands-on
course covering both fundamentals and modern aspects of mass spectrometry, with emphasis on biological and biochemical applications. Topics include: contemporary methods of gas phase ion formation [electron ionization (EI), chemical ionization (CI), inductively coupled plasma (ICP), fast atom bombardment (FAB), plasma desorption (PD), electrospray (ESI), atmospheric pressure chemical ionization (APCI), matrix assisted laser desorption ionization (MALDI), detection (electron and photomultipliers, and array detectors), and mass analysis [magnetic deflection, quadrupole, ion trap, time of flight (TOF), and Fourier-transform (FTMS)]. Detailed interpretation of organic mass spectra for structural information, with special emphasis on even-electron-ion fragmentation. Qualitative and quantitative applications in environmental, biological, pharmacological, forensic, and geochemical sciences.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics at the interface of biology and computer technology will be discussed, including molecular sequence analysis, phylogeny generation, biomolecular structure simulation, and modeling of site-directed mutagenesis.
Prerequisites:
CH 321 Theromodynamics
(3-0-3)(Lec-Lab-Credit Hours)
Laws of thermodynamics, thermodynamic functions, and the foundations of statistical thermodynamics. The chemical potential is applied to phase equilibria, chemical reaction equilibria, and solution theory, for both ideal and real systems.
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Biochemistry I - Cellular Metabolism and Regulation
(3-0-3)(Lec-Lab-Credit Hours)
Discussions include metabolic pathways in biosynthesis and catabolism of biomolecules, including carbohydrates, proteins, lipids, and nucleic acids. The hormonal regulation of metabolism, as well as vitamin metabolism, is presented.
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| | | (3-0-3) (Lec-Lab-Credit Hours)
Mechanisms and kinetics of organic and inorganic polymerization reactions; condensation, free radical and ionic addition, and stereoregular polymerizations; copolymerizations; and the nature of chemical bonds and the resul
ting physical properties of high polymers.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Physio-chemical aspects of polymers, molecular weight distributions, solution characterization and theories, polymer chain configuration, thermodynamics of polymer solutions, the amorphous state, and the crystalline state.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The course covers recent advances in macromolecular science, including polyelectrolytes and water-soluble polymers, synthetic and biological macromolecules at surfaces, self-assembly of synthetic and biological macromolecules, and polymers for biomedical applications.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Recent developments in polymer science will be discussed, e.g., physical measurements, polymer characterization, polymerization kinetics, and morphology. Topics will vary from year to year and specialists will participate.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics at the interface of polymer chemistry and biomedical sciences, focusing on areas where polymers have made a particularly strong contribution, such as in biomedical sciences and pharmaceuticals . Synthesis and properties of biopolymers; biomaterials; nanotechnology smart polymers; functional applications in biotechnology, tissue and c
ell engineering; and biosensors and drug delivery.
Prerequisites:
CH 242
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussions in medical, industrial, and environmental microbiology will include bacteriology, virology, mycology, parasitology, and infectious diseases. Includes experimental laboratory instruction. Laboratory fee: $60.
Prerequisites:
CH 382
(3-3-4)(Lec-Lab-Credit Hours)
Physiochemical principles underlying the coordinated function in multicellular organisms are studied. Electrical properties of biological membranes, characteristics of tissues, nerve-muscle electrophysiology, circulatory, respiratory, endocrine, digestive, and excretory systems are covered. Computer simulation experiments and data acquisition methods to evaluate and monitor human physiological systems are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discusses the physical and structural chemistry of proteins and nucleotides, as well as the functional role these molecules play in biochemistry. Extensive use of known X-ray structural information will be used to visualize the three-dimensional structure of these biomolecules. This structural information will be used to relate the molecules to known functional information.
Prerequisites:
CH 242
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Students will work actively in small collaborative groups to solve a unique research project that encompasses the purification, analysis of purity, kinetics, and structure-function analysis of a novel recombinant protein. Techniques in protein purification, gel electrophoresis, peptide digest separation, ligand binding, steady-state and stopped-flow kinetics, and molecular simulation will be explored. Laboratory fee: $60.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This laboratory course introduces essential techniques in molecular biology and genetic engineering in a project format. The course includes aseptic technique and the handling of microbes; isolation and purification of nucleic acids; construction, selection and analysis of recombinant DNA molecules; restriction mapping; immobilization and hybridization of nucleic acids; and labeling methods of nucleic acid probes. Laboratory fee: $60.
Prerequisites:
CH 484
(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A few topics of timely interest will be treated in depth,; recent chemical developments will be surveyed in fie
lds such as antibiotics, cancer chemotherapy, CNS agents, chemical control of fertility, steroids and prostaglandins in therapy, etc.
Prerequisites:
CH 242
(3-4-4)(Lec-Lab-Credit Hours)
Continuation of CH 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The cells and molecules of the immune system and their interaction and regulation; the cellular and genetic components of the immune response, the biochemistry of antigens and antibodies, the generation of antibody diversity, cytokines, hypersensitivities, and immunodeficiencies (i.e. AIDS); and transplants and tumors. Use of antibodies in currently emerging immunodiagnostic techniques such as ELISA, disposable kits, molecular targets, and development of vaccines utilizing molecular biological techniques, such as recombinant and subunit vaccines. Students (or groups of students) are expected to write and present a term project.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course is a modern approach to the study of heredity through molecular biology. Primary emphasis is on nucleic acids, the molecular biology of gene expression, molecular recognition and signal transduction, and bacterial and viral molecular biology. The course will also discuss recombinant DNA technology and its impact on science and medicine.
Prerequisites:
CH 484
(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A discussion of the theories underlying various techniques of molecular biology which are used in the biotechnology industry. Topics include all recombinant DNA techniques; DNA isolation and analysis; library construction and screening; cloning; DNA sequencing; hybridization and other detection methods; RNA isolation and analysis; protein isolation and analysis (immunoassay, ELISA, etc.); transgenic and ES cell methods; electrophoresis (agarose, acrylamide, two dimensional, and SDS-PAGE); column chromatography; and basic cell culture including transfection and expression systems.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Laboratory practice in modern biological research will be explored. Techniques involving gene and protein cellular probes, ELISA, mammalian cell culturing, cell cycle determination, differential centrifugation, electron microscopy, and fluorescent cellular markets will be addressed. Laboratory fee $60.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hou
rs)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This advanced course covers the mechanism and biological role of signal transduction in mammalian cells. Topics included are extracellular regulatory signals, intracellular signal transduction pathways, role of tissue context in the function of cellular regulation, and examples of biological processes controlled by specific cellular signal transduction pathways.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (1-0-0.5) (Lec-Lab-Credit Hours)
Lectures by department faculty, guest speakers, and doctoral students on recent research. Enrollment during the entire period of study is required of all doctoral s
tudents. 0.5 credit, pass/fail. Must be taken every semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics of current interest selected by you are to be investigated from an advanced point of view.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics of current interest selected by you are to be investigated from an advanced point of view.
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